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首页> 外文期刊>Psychiatric genetics >Identification of genetic variants in the neuronal form of tryptophan hydroxylase (TPH2).
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Identification of genetic variants in the neuronal form of tryptophan hydroxylase (TPH2).

机译：鉴定色氨酸羟化酶（TPH2）神经元形式的遗传变异。

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OBJECTIVE: We screened the complete protein coding sequence of the newly identified neuronal form of tryptophan hydroxylase (TPH2) for genetic variants. METHODS: Genomic DNA samples from 24 African-Americans and 24 Caucasian-Americans in the Coriell human variation collection were screened by denaturing high-performance liquid chromatography followed by sequencing. RESULTS: We identified a number of genetic variants in both the coding and exon-flanking intronic sequences. Only one variant was identified that predicts a structural change in the TPH2 protein, and this was seen in only one out of 96 chromosomes. CONCLUSIONS: The gene for TPH2 contains a number of polymorphisms that might serve as useful markers for association analyses of complex behavioral phenotypes or as actual risk factors. Structural polymorphisms are extremely rare in TPH2 and cannot therefore act as substantial risk factors for behavioral disorders in African-American and Caucasian populations.
机译：目的：我们筛选了新鉴定出的色氨酸羟化酶（TPH2）神经元形式的遗传变异的完整蛋白质编码序列。方法：通过变性高效液相色谱，然后进行测序，筛选来自Coriell人类变异收集物中的24位非裔美国人和24位高加索裔美国人的基因组DNA样品。结果：我们在编码和外显子侧翼内含子序列中均鉴定出许多遗传变异。仅鉴定出一种可预测TPH2蛋白结构变化的变体，在96条染色体中只有一条可见。结论：TPH2基因包含许多多态性，可作为复杂行为表型关联分析或实际危险因素的有用标记。结构多态性在TPH2中极为罕见，因此不能作为非裔美国人和高加索人群行为障碍的重要危险因素。

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