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Replication association analysis of S100B and cognitive ageing.

机译:S100B的复制关联分析与认知老化。

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摘要

The calcium-binding protein S100B is predominantly expressed by astrocytes in the human brain and is a putative marker of brain injury. A genetic variant in S100 calcium-binding protein B (S100B) has been associated with low cognitive performance and dementia in the elderly (Lambert et al., 2007). We tested this genetic variant (rs2300403) for association with cognitive abilities and lifetime cognitive ageing in approximately 1000 elderly Scots: the Lothian Birth Cohort 1936 (LBG1936).
机译:钙结合蛋白S100B主要由人脑中的星形胶质细胞表达,是脑损伤的推测标志。 S100钙结合蛋白B(S100B)的遗传变异与老年人的低认知能力和痴呆症有关(Lambert et al。,2007)。我们测试了这种遗传变异(rs2300403)与大约1000名苏格兰老人的认知能力和终生认知衰老的关系:Lothian Birth Cohort 1936(LBG1936)。

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