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首页> 外文期刊>Progress in brain research >Neuronal gene expression profiling: uncovering the molecular biology of neurodegenerative disease.
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Neuronal gene expression profiling: uncovering the molecular biology of neurodegenerative disease.

机译：神经元基因表达谱：揭示神经退行性疾病的分子生物学。

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摘要

The development of gene array techniques to quantify expression levels of dozens to thousands of genes simultaneously within selected tissue samples from control and diseased brain has enabled researchers to generate expression profiles of vulnerable neuronal populations in several neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, schizophrenia, multiple sclerosis, and Creutzfeld-Jakob disease. Intriguingly, gene expression analysis reveals that vulnerable brain regions in many of these diseases share putative pathogenetic alterations in common classes of genes, including decrements in synaptic transcript levels and increments in immune response transcripts. Thus, gene expression profiles of diseased neuronal populations may reveal mechanistic clues to the molecular pathogenesis underlying various neurological diseases and aid in identifying potential therapeutic targets. This chapter will review how regional and single cell gene array technologies have advanced our understanding of the genetics of human neurological disease.
机译：基因阵列技术的发展，可以同时量化来自对照和患病大脑的选定组织样本中数十至数千个基因的表达水平，这使研究人员能够生成多种神经退行性疾病（包括阿尔茨海默氏病，帕金森氏病，精神分裂症）中脆弱神经元群体的表达谱，多发性硬化症和Creutzfeld-Jakob病。有趣的是，基因表达分析表明，在许多这类疾病中，脆弱的大脑区域在常见的基因类别中均具有假定的致病性改变，包括突触转录水平的降低和免疫应答转录水平的提高。因此，患病的神经元群体的基因表达谱可能揭示各种神经疾病基础分子发病机制的机制线索，并有助于确定潜在的治疗靶点。本章将回顾区域和单细胞基因阵列技术如何增进我们对人类神经系统疾病遗传学的理解。

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