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首页> 外文期刊>Progress in Cardiovascular Diseases >Safety issues in pharmacotherapy for smoking in patients with cardiovascular disease.
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Safety issues in pharmacotherapy for smoking in patients with cardiovascular disease.

机译：心血管疾病患者吸烟的药物治疗中的安全性问题。

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摘要

Twenty percent of patients with cardiovascular disease smoke, and smoking cessation results in a dramatic decline in the relative risk of future cardiovascular events. Questions regarding the safety of nicotine-replacement therapy and bupropion SR for smoking cessation in patients with cardiovascular disease have arisen, in particular because of potential hemodynamic effects of these agents. There have been several randomized, controlled, clinical trials testing the safety of transdermal nicotine in patients with cardiovascular disease that failed to show an increased risk for cardiac events in active treatment conditions compared with placebo. Efficacy trials conducted in other patient populations also support the safety of nicotine-replacement use in cardiac disease patients. To date there is one randomized controlled trial to test bupropion for smoking cessation conducted in this population. Studies to test the efficacy of bupropion for smoking cessation and depression suggest it is safe to use in cardiac disease patients despite recent case reports of adverse events associated with bupropion use. Nicotine-replacement therapy and bupropion significantly increase long-term smoking cessation rates, and the benefits of cessation exceed the risks for pharmacotherapy in patients with cardiovascular disease.
机译：患有心血管疾病的患者中有20％吸烟，并且戒烟导致未来心血管事件的相对风险急剧下降。出现了有关尼古丁替代疗法和安非他酮SR在心血管疾病患者戒烟中的安全性的问题，特别是由于这些药物的潜在血液动力学效应。有几项随机，对照，临床试验测试了经皮尼古丁在心血管疾病患者中的安全性，与安慰剂相比，该试验未能显示出在积极治疗条件下发生心脏事件的风险增加。在其他患者人群中进行的功效试验也支持心脏病患者使用尼古丁替代品的安全性。迄今为止，有一项针对该人群进行的安非他酮戒烟试验的随机对照试验。测试安非他酮对戒烟和抑郁的功效的研究表明，尽管最近有关于使用安非他酮相关不良事件的病例报道，但在心脏病患者中仍可安全使用。尼古丁替代疗法和安非他酮显着提高了长期戒烟率，戒烟的好处超过了心血管疾病患者药物治疗的风险。

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