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首页> 外文期刊>Progress in Cardiovascular Diseases >Cigarette smoking and coronary blood flow.
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Cigarette smoking and coronary blood flow.

机译：吸烟和冠状动脉血流。

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Cigarette smoking is associated with an increased risk for vascular disease. The effects of smoking and nicotine on coronary and peripheral arterial function have been probed with various invasive and noninvasive techniques. The current review provides a brief summary of the available techniques for measuring coronary or peripheral arterial function and discusses the determinants of myocardial blood flow at rest and during stress. Finally, it summarizes research addressing the effects of smoking on coronary and peripheral arterial function. Acute and chronic smoking does not appear to alter substantially endothelium independent coronary vasodilatory capacity. In contrast, active and passive smoking alters coronary and peripheral arterial vasomotion in patients with and individuals without coronary artery disease (CAD). Therefore, the site of the damaging effects of smoking appears to be the coronary endothelium. The smoking history is correlated with the degree of vasomotor abnormalities. Further, the degree of smoking-induced endothelial dysfunction appears to increase with the severity of CAD. Finally, the coronary endothelial and peripheral arterial vasomotor dysfunction observed in active and passive healthy smokers appear to be to some degree reversible. Copyright 2003, Elsevier Science (USA). All rights reserved.
机译：吸烟与血管疾病的风险增加有关。吸烟和尼古丁对冠状动脉和外周动脉功能的影响已通过各种侵入性和非侵入性技术进行了探讨。本篇综述简要介绍了用于测量冠状动脉或外周动脉功能的可用技术，并讨论了静息时和应激时心肌血流的决定因素。最后，它总结了针对吸烟对冠状动脉和外周动脉功能的影响的研究。急性和慢性吸烟似乎并未实质性改变内皮独立性冠状血管扩张能力。相反，主动吸烟和被动吸烟会改变患有冠心病（CAD）和没有冠心病（CAD）的患者的冠状动脉和外周动脉血管运动。因此，吸烟破坏作用的部位似乎是冠状内皮。吸烟史与血管舒缩异常程度相关。此外，吸烟引起的内皮功能障碍的程度似乎随着CAD的严重程度而增加。最后，在主动和被动健康吸烟者中观察到的冠状动脉内皮和外周动脉血管舒缩功能障碍在某种程度上是可逆的。版权所有（Elsevier Science）（美国），2003年。版权所有。

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