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首页> 外文期刊>Progress in Cardiovascular Diseases >Role of thrombotic and fibrinolytic factors in acute coronary syndromes.
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Role of thrombotic and fibrinolytic factors in acute coronary syndromes.

机译:血栓和纤溶因子在急性冠脉综合征中的作用。

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摘要

There is a growing body of literature concerning the contribution of hemostatic factors to the development of cardiovascular disease. The mechanisms of the coagulation/fibrinolytic system are complicated and one factor is intimately interrelated with another; thus the contribution of each factor cannot be clearly understood, unless hemostatic factors are considered in accordance with endothelial function and vessel morphology. Although there are many clinical studies about the correlation between hemostatic factors and cardiovascular risk, the results are inconsistent and conflicting at times. Fibrinogen and D-dimer are associated with atherosclerosis or coronary events across multiple studies, even after multivariate adjustment. But the hemostatic factors are intimately correlated, so it can be said that focusing on one to the exclusion of others is inappropriate. The clinical trials with statins or angiotensin converting enzyme inhibitors have shown favorable effects on the prognosis of cardiovascular disease. The study of hemostatic factors in relation to these drugs has provided insights into understanding how these drugs produce beneficial effects.
机译:关于止血因素对心血管疾病发展的贡献的文献越来越多。凝血/纤维蛋白溶解系统的机制很复杂,一个因素与另一个因素密切相关。因此,除非根据血管内皮功能和血管形态来考虑止血因素,否则无法清楚地理解每种因素的作用。尽管有许多关于止血因素与心血管风险之间关系的临床研究,但结果有时不一致且矛盾。在多项研究中,即使经过多变量调整,纤维蛋白原和D-二聚体也与动脉粥样硬化或冠脉事件相关。但是止血因素密切相关,因此可以说,只专注于一个因素而排除其他因素是不合适的。他汀类药物或血管紧张素转化酶抑制剂的临床试验已显示出对心血管疾病预后的有利影响。与这些药物有关的止血因素的研究为理解这些药物如何产生有益作用提供了见识。

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