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首页> 外文期刊>Progress in brain research >The course of cellular alterations associated with the development of spontaneous seizures after status epilepticus.
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The course of cellular alterations associated with the development of spontaneous seizures after status epilepticus.

机译：癫痫持续状态后，与自然发作有关的细胞变化过程。

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Chronic epilepsy, as a consequence of status epilepticus, has been studied in animal models in order to analyze the cellular mechanisms responsible for the subsequent occurrence of spontaneous seizures. Status epilepticus, induced by either kainic acid or pilocarpine or by prolonged electrical stimulation, causes a characteristic pattern of neuronal death in the hippocampus; which is followed--after an apparent latent period--by the development of chronic, recurrent, spontaneous seizures. The question most relevant to this conference is the degree to which the subsequent chronic seizures contribute further to epileptogenesis and brain damage. This article addresses the temporal and anatomical parameters that must be understood in order to address this question. (1) How does one evaluate experimentally whether the chronic epileptic seizures that follow status epilepticus contribute to epileptogenesis and lead to brain damage? To answer this question, we must first know the time course of the developmentof the chronic epileptic seizures, and whether the interval between subsequent individual chronic seizures is a relevant factor. (2) What anatomical parameters are most relevant to the progression of epilepsy? For instance, how does loss of inhibitory interneurons potentially influence seizure generation and the progressive development of epileptogenesis? Does axon sprouting and formation of new synaptic connections represent a form of seizure-induced brain damage? These specific issues bear directly on the general question of whether seizures damage the brain during the chronic epilepsy that follows status epilepticus.
机译：在动物模型中研究了由于癫痫持续状态而引起的慢性癫痫，以便分析引起随后自发性癫痫发作的细胞机制。海藻酸或毛果芸香碱或长时间的电刺激引起的癫痫持续状态导致海马神经元死亡的特征性模式;在明显的潜伏期之后，接着是慢性，反复发作，自发性癫痫发作。与这次会议最相关的问题是随后的慢性癫痫发作进一步加剧癫痫发生和脑损伤的程度。本文介绍了为了解决这个问题必须理解的颞和解剖参数。 （1）如何通过实验评估在癫痫持续状态后发生的慢性癫痫发作是否有助于癫痫发生并导致脑损伤？要回答这个问题，我们首先必须知道慢性癫痫发作发展的时间过程，以及随后的各个慢性癫痫发作之间的间隔是否是一个相关因素。 （2）哪些解剖学参数与癫痫的发展最相关？例如，抑制性中间神经元的丧失如何影响癫痫发作的发生和癫痫发生的发展？轴突萌发和新的突触连接的形成代表癫痫发作引起的脑损伤吗？这些具体问题直接关系到癫痫持续状态之后的慢性癫痫发作中癫痫是否会损害大脑的一般性问题。

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