Spinal cord contusion models.

Young W

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Spinal cord contusion models.

机译：脊髓挫伤模型。

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Most human spinal cord injuries involve contusions of the spinal cord. Many investigators have long used weight-drop contusion animal models to study the pathophysiology and genetic responses of spinal cord injury. All spinal cord injury therapies tested to date in clinical trial were validated in such models. In recent years, the trend has been towards use of rats for spinal cord injury studies. The MASCIS Impactor is a well-standardized rat spinal cord contusion model that produces very consistent graded spinal cord damage that linearly predicts 24-h lesion volumes, 6-week white matter sparing, and locomotor recovery in rats. All aspects of the model, including anesthesia for male and female rats, age rather than body weight criteria, and arterial blood gases were empirically selected to enhance the consistency of injury.

机译：大多数人类脊髓损伤都涉及脊髓挫伤。许多研究人员长期以来一直使用减重挫伤动物模型来研究脊髓损伤的病理生理和遗传反应。在此类模型中验证了迄今为止在临床试验中测试的所有脊髓损伤疗法。近年来，趋向于将大鼠用于脊髓损伤研究。 MASCIS Impactor是一个标准化的大鼠脊髓挫伤模型，可产生非常一致的分级脊髓损伤，线性预测大鼠的24小时病变量，6周白质保留和运动恢复。该模型的所有方面，包括雄性和雌性大鼠的麻醉，年龄而不是体重标准以及动脉血气都是根据经验选择的，以增强损伤的一致性。

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《Progress in brain research》 |2002年第0期|共25页
作者
Young W;
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正文语种 eng
中图分类神经病学与精神病学;
关键词
Spinal Cord Injuries; 脊髓损伤;

机译：Spinal Cord Injuries;脊髓损伤;

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专利

1. Spinal cord contusion models. [J] . Young W Progress in brain research . 2002,第0期

机译：脊髓挫伤模型。
2. Involvement of Shh/Gli1 signaling in the permeability of blood-spinal cord barrier and locomotion recovery after spinal cord contusion [J] . Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 2020,第期

机译：SHH / GLI1信号传导在脊髓挫伤后血脊髓屏障和运动恢复的渗透性
3. Convolutional Neural Network-Based Automated Segmentation of the Spinal Cord and Contusion Injury: Deep Learning Biomarker Correlates of Motor Impairment in Acute Spinal Cord Injury [J] . Mccoy D. B., Dupont S. M., Gros C., AJNR. American journal of neuroradiology . 2019,第4期

机译：基于锥形神经网络的脊髓和挫伤损伤自动分割：深度学习生物标志物在急性脊髓损伤中的电动机损伤相关联
4. A chemist’s view of inflammation in contusion injured spinal cord in a rat model: noninvasive, noncontact, in vivo Raman spectroscopy minutes to hours after injury [C] . Seth Fillioe, Kyle Kelly Bishop, Sai Han Tun, Photonic Diagnosis and Treatment of Infections and Inflammatory Diseases II . 2019

机译：化学家对大鼠模型中挫伤性脊髓损伤的炎症看法：损伤后数分钟至数小时的无创，非接触式体内拉曼光谱
5. Correlation of diffusion tensor imaging indices with histological parameters in rat cervical spinal cord gray matter following distal contusion spinal cord injury. [D] . Mottackel, Robin E. 2010

机译：远端挫伤性脊髓损伤后大鼠颈脊髓灰质扩散张量成像指标与组织学参数的相关性。
6. Convolutional Neural Network–Based Automated Segmentation of the Spinal Cord and Contusion Injury: Deep Learning Biomarker Correlates of Motor Impairment in Acute Spinal Cord Injury [O] . D.B. McCoy, S.M. Dupont, C. Gros, 2019

机译：基于卷积神经网络的脊髓和挫伤损伤的自动分割：深度学习生物标志物与急性脊髓损伤中运动障碍的相关性
7. Motor cortex and spinal cord neuromodulation promote corticospinal tract axonal outgrowth and motor recovery after cervical contusion spinal cord injury [O] . N. Zareen, M. Shinozaki, D. Ryan, 2017

机译：电机皮质和脊髓神经调节促进宫颈挫伤脊髓损伤后的皮质脊髓轴突轴突口和电动机恢复

Spinal cord contusion models.

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