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首页> 外文期刊>Progress in brain research >Bottom-up transfer of sensory-motor plasticity to recovery of spatial cognition: visuomotor adaptation and spatial neglect.
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Bottom-up transfer of sensory-motor plasticity to recovery of spatial cognition: visuomotor adaptation and spatial neglect.

机译：自下而上的感觉运动可塑性转移到空间认知的恢复：视觉运动适应和空间忽视。

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A large proportion of right-hemisphere stroke patients show hemispatial neglect, a neurological deficit of perception, attention, representation, and/or performing actions within their left-sided space, inducing many functional debilitating effects on everyday life, and responsible for poor functional recovery and ability to benefit from treatment. This spatial cognition disorder affects the orientation of behavior with a shift of proprioceptive representations toward the lesion side. This shift is similar to that produced by psychophysical manipulations as a wedge-prism exposure in normal healthy subjects. In both subjects, one major compensative effect of short-term prism adaptation is a shift of proprioceptive representations, demonstrated by a shift in manual straight-ahead pointing in the dark, in a direction opposite to the visual shift. In neglect patients, prism adaptation involves the shift of proprioceptive representations to the left with a reduction of rightward bias observed in neglect patients in visuo-manual tasks as line-bisection, line-cancellation or copy drawing. Improvement of neglect is also observed in no visuo-manual tasks as mental imagery, auditory extinction or posture. This generalization of prism adaptation effects at different neglect level symptoms suggests that the process of prism adaptation may activate brain functions related to multisensory integration and higher spatial representations. Moreover the positive effects found for both sensorimotor and more cognitive spatial functions lasted for at least two or more hours after prism removal. Unlike reduction of neglect through sensory stimulations, the long-lasting improvement of neglect after prism adaptation suggests the activation of short-term plasticity of brain functions related to coordinate transformations and space representations. Lastly, the duration of these effects could be useful in rehabilitation programs, as suggested by the effects of prism adaptation on disabling neglect symptoms as wheelchair driving, posture or writing.
机译：右半球中风患者中有很大一部分表现出半身偏瘫，左侧空间内的知觉，注意力，代表和/或执行动作的神经系统缺陷，对日常生活造成许多功能虚弱的影响，并导致功能恢复不良以及从治疗中受益的能力。这种空间认知障碍会通过本体感受表示向病变侧的转移来影响行为的方向。这种变化类似于在正常健康受试者中通过楔形棱镜暴露而进行的心理物理操作所产生的变化。在这两个对象中，短期棱镜适应的一个主要补偿作用是本体感受表示的偏移，这通过在黑暗中手动笔直向前指向与视觉偏移相反的方向来证明。在被忽视的患者中，棱柱适应涉及将本体感受性表示向左移动，而在手动操作（例如，线平分，取消线或复制图）中，在忽略的患者中观察到的向右偏差减小。在没有任何视觉图像，听觉消瘦或姿势等视觉任务中，也观察到了疏忽的改善。棱镜适应效果在不同的忽略水平症状下的这种概括表明，棱镜适应的过程可能会激活与多感觉整合和更高空间表示有关的大脑功能。此外，在去除棱镜后，对感觉运动功能和更多认知空间功能的积极影响至少持续了两个小时或更长时间。与通过感觉刺激减少疏忽不同，棱镜适应后疏忽的长期改善表明与坐标转换和空间表征有关的大脑功能的短期可塑性被激活。最后，这些影响的持续时间在康复计划中可能是有用的，如棱镜适应对禁用轮椅驾驶，姿势或书写等疏忽症状的影响所暗示的那样。

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