...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Progress in brain research >Trafficking the NGF signal: implications for normal and degenerating neurons.
【24h】

Trafficking the NGF signal: implications for normal and degenerating neurons.

机译：贩运NGF信号：对正常和退化神经元的影响。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Nerve growth factor (NGF) activates TrkA to trigger signaling events that promote the survival, differentiation and maintenance of neurons. The mechanism(s) that controls the retrograde transport of the NGF signal from axon terminals to neuron cell bodies is not known. The 'signaling endosome' hypothesis stipulates that NGF, TrkA and signaling proteins are retrogradely transported on endocytic vesicles. Here, we provide evidence for the existence of signaling endosomes. Following NGF treatment, clathrin-coated vesicles (CCVs) contain NGF bound to TrkA together with activated signaling proteins of the Ras/pErk1/2 pathway. NGF signals from isolated CCVs through the Erk1/2 pathway. Early endosomes appear to represent a second type of signaling endosomes. We found that NGF induced a sustained activation of Rap1, a small monomeric GTP-binding protein of the Ras family, and that this activation occurred in early endosomes that contain key elements of Rap1/pErk1/2 pathway. We discuss the possibility that the failure of retrograde NGF signaling in a mouse model of Down syndrome (Ts65Dn) may be due to the failure to retrograde transport signaling endosomes. It is important to define further the significance of signaling endosomes in the biology of both normal and degenerating neurons.
机译：神经生长因子（NGF）激活TrkA以触发信号传导事件，从而促进神经元的存活，分化和维持。控制NGF信号从轴突末端到神经元细胞体的逆行运输的机制尚不清楚。 “信号内体”假说规定，NGF，TrkA和信号蛋白在细胞吞噬小泡上逆行转运。在这里，我们提供了信号内体存在的证据。 NGF处理后，网格蛋白包被的囊泡（CCV）包含与TrkA结合的NGF以及Ras / pErk1 / 2途径的活化信号蛋白。来自孤立CCV的NGF信号通过Erk1 / 2途径。早期的内体似乎代表了第二种信号内体。我们发现NGF诱导了Ras家族（Ras家族的一种小单体GTP结合蛋白）的持续激活，并且这种激活发生在包含Rap1 / pErk1 / 2途径关键要素的早期内体中。我们讨论了唐氏综合症（Ts65Dn）小鼠模型中NGF信号逆行失败的可能是由于逆向运输信号内体的失败。重要的是进一步定义信号内体在正常和退化神经元生物学中的重要性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号