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Does 5HTTLPR long allele prevent hospitalization? Test of Hardy-Weinberg equilibrium

机译：5HTTLPR长等位基因可以预防住院吗？ Hardy-Weinberg平衡的检验

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Many studies suggest an association of the serotonin transporter gene polymorphism (5HTTLPR) long allele with better antidepressant treatment response than the short allele. However, there is controversy over these findings. We hypothesized that if the long allele is associated with a better outcome, we would find fewer inpatients with the long allele compared with the short allele. Chart review identified 925 depressed inpatients and 201 outpatients genotyped for 5HTTLPR. The sample was primarily White (>90%). We tested potential departures from Hardy-Weinberg equilibrium for each sample. We analyzed three independent sets of inpatient samples separately and combined, a White subgroup of 791 patients of the total 925 inpatients, and 201 outpatients. There was no departure from Hardy-Weinberg equilibrium with any of these samples. We also compared 5HTTLPR genotype prevalence between 925 inpatients and 201 outpatients, which showed no statistically significant difference.
机译：许多研究表明，血清素转运蛋白基因多态性（5HTTLPR）长等位基因比短等位基因具有更好的抗抑郁治疗反应。但是，这些发现存在争议。我们假设，如果长等位基因与更好的预后相关，那么与短等位基因相比，我们将发现长等位基因的住院患者更少。图表审查确定了925名抑郁住院患者和201名门诊患者5HTTLPR基因型。样品主要为白色（> 90％）。我们测试了每个样本与Hardy-Weinberg平衡的潜在偏差。我们分别分析了三组独立的住院样本，并进行了合并分析，一个白人亚组共925名住院患者中的791名患者和201名门诊患者。这些样本都没有偏离Hardy-Weinberg平衡。我们还比较了925位住院患者和201位门诊患者之间的5HTTLPR基因型患病率，但无统计学差异。

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