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首页> 外文期刊>Progress in brain research >Laminar circuit formation in the vertebrate retina.
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Laminar circuit formation in the vertebrate retina.

机译:脊椎动物视网膜中的层流回路形成。

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摘要

Neuronal function depends on the accurate wiring between pre- and postsynaptic cells. Determining the mechanisms underlying precision in neuronal connectivity is challenging because of the complexity of the nervous system. In diverse parts of the nervous system, regions of synaptic contact are organized into distinct parallel layers, or laminae, that are correlated with distinct functions. Such an arrangement enables the development of synapse specificity to be more readily investigated. Here, we present an overview of the developmental mechanisms that are thought to underlie the formation of synaptic layers in the vertebrate retina, a highly laminated CNS structure. We will contrast the roles of activity-dependent and activity-independent mechanisms in establishing functionally discrete sublaminae in the inner retina, where circuits involving many subtypes of retinal neurons are assembled precisely. In addition, we will discuss new optical imaging approaches for elucidating how retinal synaptic lamination occurs in vivo.
机译:神经元功能取决于突触前和突触后细胞之间的准确连接。由于神经系统的复杂性,确定神经元连接的精确度背后的机制具有挑战性。在神经系统的不同部分,突触接触的区域被组织成不同的平行层或薄片,这些层与不同的功能相关。这样的安排使突触特异性的发展更容易被研究。在这里,我们提出了发展机制的概述,这些机制被认为是脊椎动物视网膜(高度层压的CNS结构)中突触层形成的基础。我们将对比活动依赖和活动独立机制在内部视网膜中建立功能离散的薄层的作用的对比,在视网膜内部层中,涉及许多亚型视网膜神经元的回路被精确组装。此外,我们将讨论新的光学成像方法,以阐明视网膜突触层压在体内如何发生。

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