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首页> 外文期刊>Progress in brain research >Integration of metabolic stimuli in the hypothalamic arcuate nucleus.
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Integration of metabolic stimuli in the hypothalamic arcuate nucleus.

机译：下丘脑弓状核中代谢刺激的整合。

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摘要

Integration of peripheral and central anabolic and catabolic inputs within the hypothalamic arcuate nucleus (ARC) is believed to be central to the maintenance of energy balance. In order to perform this complex task, neurons in the ARC express receptors for all major humoral and central transmitters involved in the maintenance of energy homeostasis. The integration of these inputs occurs at the cellular and circuit level and the resulting electrical output forms the origins for the activation of feeding and energy balance-related networks. Here, we discuss the role that active intrinsic membrane conductances, K(ATP) channels and intracellular second messenger systems play in the integration of metabolic stimuli at the cellular level in the ARC. We conclude that the research into the integration of hunger and satiety signals in the ARC has made substantial progress in the last decade, but we are far from unraveling the complex neuronal networks involved in the maintenance of energy homeostasis. The diverse range of inputs, neuronal integrative properties, targets, output signals and how these signals relate to the physiological output provides us with a colossal challenge for years to come. However, to battle the current obesity epidemic, target-specific drugs need to be developed for which the knowledge of neuronal pathways involved in the maintenance of energy homeostasis will be crucial.
机译：下丘脑弓状核（ARC）周围和中央合成代谢和分解代谢输入的整合被认为是维持能量平衡的关键。为了执行这项复杂的任务，ARC中的神经元表达了参与能量体内平衡维持的所有主要体液和中央递质的受体。这些输入的集成发生在蜂窝和电路级，并且产生的电输出形成了激活馈电和能量平衡相关网络的起源。在这里，我们讨论了主动内在膜电导，K（ATP）通道和细胞内第二信使系统在ARC细胞水平上的代谢刺激整合中所扮演的角色。我们得出的结论是，在过去的十年中，对ARC中的饥饿和饱足信号的集成的研究取得了实质性进展，但我们还没有弄清涉及维持能量稳态的复杂神经元网络。输入，神经元整合特性，目标，输出信号以及这些信号与生理输出之间的关系的多样性为我们提供了巨大的挑战。然而，为了对抗当前的肥胖病流行，需要开发针对特定靶标的药物，对于这些药物而言，与维持能量稳态有关的神经途径的知识将至关重要。

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