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首页> 外文期刊>Progress in brain research >The pars reticulata of the substantia nigra: a window to basal ganglia output.
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The pars reticulata of the substantia nigra: a window to basal ganglia output.

机译:黑质的pars reticulata:基底神经节输出的窗口。

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Together with the internal segment of the globus pallidus (GP(i)), the pars reticulata of the substantia nigra (SNr) provides a main output nucleus of the basal ganglia (BG) where the final stage of information processing within this system takes place. In the last decade, progress on the anatomical organization and functional properties of BG output neurons have shed some light on the mechanisms of integration taking place in these nuclei and leading to normal and pathological BG outflow. In this review focused on the SNr, after describing how the anatomical arrangement of nigral cells and their afferents determines specific input-output registers, we examine how the basic electrophysiological properties of the cells and their interaction with synaptic inputs contribute to the spatio-temporal shaping of BG output. The reported data show that the intrinsic membrane properties of the neurons subserves a tonic discharge allowing BG to gate the transmission of information to motor and cognitive systems thereby contributing to appropriate selection of behavior.
机译:黑质黑质(SNr)连同苍白球(GP(i))的内部部分一起提供了基底神经节(BG)的主要输出核,在此系统中信息处理的最后阶段发生。在过去的十年中,BG输出神经元在解剖组织和功能特性方面的进展为这些核中发生的整合机制以及正常和病理性BG流出提供了一些线索。在这篇关于SNr的综述中,在描述了黑细胞及其传入的解剖结构如何确定特定的输入-输出寄存器后,我们研究了细胞的基本电生理特性以及它们与突触输入的相互作用如何促进时空塑形。 BG输出。报道的数据表明,神经元的固有膜特性可保留补品放电,使BG能够控制信息向运动和认知系统的传递,从而有助于行为的适当选择。

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