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首页> 外文期刊>Public Health Nutrition >High-dose vitamin C supplement use is associated with self-reported histories of breast cancer and other illnesses in the UK Women's Cohort Study.
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High-dose vitamin C supplement use is associated with self-reported histories of breast cancer and other illnesses in the UK Women's Cohort Study.

机译：在英国女性队列研究中，高剂量维生素C补充剂的使用与乳腺癌和其他疾病的自我报告史有关。

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Objective - To determine whether frequent vitamin C supplement use is associated with healthier behaviours, and a history of cancer and other illnesses in UK women. Design - The present cross-sectional analysis examines the odds of taking supplements containing vitamin C as recorded in 4 d food diaries, based on lifestyle characteristics and morbidity history self-reported by questionnaire. Setting - A large national UK cohort study. Subjects - A total of 12 453 women aged between 37 and 79 years. Results - Women frequently taking supplements containing vitamin C, compared to those who did not, had healthier behaviours, including higher consumption of fruit and vegetables. Frequent high-dose vitamin C users (>=1000 mg) had a higher socio-economic status, visited alternative practitioners more often than family or private doctors, and were more likely to be ex-smokers and to drink little or no alcohol. Women who self-reported having had cancer (OR=1.33, 95% CI 1.00, 1.76) or specifically breast cancer (OR=1.70, 95% CI 1.14, 2.55), or reported a family history of cancer (OR=1.16, 95% CI 0.95, 1.41) or breast cancer (OR=1.26, 95% CI 1.01, 1.58) had increased odds of being frequent high-dose users after adjusting for sociodemographic and health behaviours. Women with personal or family histories of some cardiovascular or intestinal disorders were more likely to take supplements containing vitamin C, though not necessarily at high doses. Conclusions - High-dose vitamin C intake by UK women was associated with healthier behaviours and a history of breast cancer, total cancer and other illnesses. Consequences of high-dose vitamin C supplement intake are not clear at the population level.
机译：目的-确定英国妇女频繁使用维生素C补充剂是否与更健康的行为以及癌症和其他疾病史相关。设计-本横断面分析根据问卷调查报告的生活方式特征和发病历史，检查了4 d食品日记中记录的服用含维生素C补充剂的几率。设置-大型英国国家队列研究。受试者-共有12 453名年龄在37至79岁之间的女性。结果-与未服用维生素C的女性相比，经常服用含维生素C的女性的行为更为健康，包括大量食用水果和蔬菜。经常使用大剂量维生素C的用户（> = 1000 mg）具有较高的社会经济地位，比家庭医生或私人医生更经常拜访替代从业者，并且更可能是前吸烟者且几乎不喝酒或不喝酒。自我报告患有癌症（OR = 1.33，95％CI 1.00，1.76）或特别是乳腺癌（OR = 1.70，95％CI 1.14，2.55）或报告有癌症家族史（OR = 1.16，95）的女性％CI 0.95，1.41）或乳腺癌（OR = 1.26，95％CI 1.01，1.58）在调整了社会人口统计学和健康行为后增加了经常服用大剂量药物的几率。具有某些心血管或肠道疾病的个人或家族病史的妇女更可能服用含维生素C的补品，尽管不一定要高剂量。结论-英国妇女高剂量摄入维生素C与更健康的行为以及乳腺癌，全癌和其他疾病的病史有关。在人群中尚不清楚高剂量维生素C补充剂摄入的后果。

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