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Dietary consumption of phytochemicals and breast cancer risk in Mexican women.

机译:墨西哥妇女的饮食中植物化学物质的摄入和患乳腺癌的风险。

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Objective: To perform an evaluation of selected phytochemicals intake and breast cancer (BC) risk in Mexican women. Design: We conducted hospital-based case-control study. Setting: Mexico City between 1994 and 1996. Subjects: A total of 141 histologically confirmed BC cases were age-matched (+or-3 years) to an equal number of hospital controls. The reproductive history of each woman was obtained by direct interview. The dietary consumption of flavonols, flavones, flavan-3-ols, cinnamic acid, lariciresinol, pinoresinol, secoisolariciresinol, matairesinol and coumestrol was obtained by means of a validated FFQ. Results: Among postmenopausal women, high dietary intake of flavonols and flavones was associated with a significant reduction of BC risk (high v. low tertile: OR=0.21, 95% CI 0.07, 0.60, P for trend=0.004 and OR=0.29, 95% CI 0.10, 0.82, P for trend=0.025, respectively); consumption of lignans (lariciresinol and pinoresinol) showed a similar effect, but only among premenopausal women (high v. low tertile: OR=0.32, 95% CI 0.10, 0.99, P for trend=0.051 and OR=0.19, 95% CI 0.06, 0.62, P for trend=0.006, respectively). Conclusions: Our results support a protective role of specific dietary phytochemicals in BC risk by menopausal status, independent of other reproductive factors.
机译:目的:对墨西哥妇女进行某些植物化学物质摄入和乳腺癌(BC)风险的评估。设计:我们进行了基于医院的病例对照研究。地点:1994年至1996年之间的墨西哥城。受试者:总共141例经组织学证实的BC病例与年龄相同(+或3岁)的同等数量的医院控制者相匹配。通过直接访谈获得每个妇女的生殖史。黄酮醇,黄酮,flavan-3-ols,肉桂酸,lariciresinol,pinoresinol,secoisolariciresinol,matairesinol和coumestrol的饮食消耗通过有效的FFQ获得。结果:绝经后妇女中,饮食中摄入黄酮醇和黄酮的含量与显着降低BC风险有关(高 v。低三分位数:OR = 0.21,95%CI 0.07,0.60,趋势= 0.004的P 和OR = 0.29,趋势= 0.025的95%CI为0.10、0.82, P );食用木脂素(lariciresinol和pinoresinol)显示出类似的效果,但仅在绝经前妇女(高 v。低三分位:OR = 0.32、95%CI 0.10、0.99, P >对于趋势= 0.051和OR = 0.19,对于趋势= 0.006,分别为95%CI 0.06、0.62和 P 。结论:我们的结果支持特定饮食植物化学物质在绝经状态下对BC风险的保护作用,而与其他生殖因素无关。

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