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首页> 外文期刊>Public Health Nutrition >The impact of prenatal vitamin A and zinc supplementation on growth of children up to 2 years of age in rural Java, Indonesia.
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The impact of prenatal vitamin A and zinc supplementation on growth of children up to 2 years of age in rural Java, Indonesia.

机译：印度尼西亚爪哇农村地区，产前维生素A和补锌对2岁以下儿童生长发育的影响。

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Objective. To determine whether prenatal vitamin A and/or Zn supplementation affects postnatal growth. Design. Follow-up of a randomized controlled trial monitoring growth in children from birth up to 24 months of age. Setting. Central Java, Indonesia. Subjects. Children (n 343) of mothers participating in a double-blinded, randomized controlled study of vitamin A and/or Zn supplementation during pregnancy. We report the effects of prenatal supplementation on infant growth, measured as weight-for-age Z-scores (WAZ), height-for-age Z-scores (HAZ) and weight-for-height Z-scores (WHZ), from 0 to 24 months, as well as differences in growth faltering among the supplementation groups. Results. For HAZ, the absolute differences between the vitamin A-only and vitamin A + Zn groups at 3 and 9 months were 0.34 SD and 0.37 SD, respectively, and the absolute difference between the vitamin A-only and Zn-only groups at 18 months was 0.31 SD. Compared with placebo, none of the supplements affected growth. Defining growth faltering as a downward crossing of two or more major percentile lines, 50-75% of the children were found to be growth faltering within 9 months of age, whereas 17% and 8% scored <--2 SD for WAZ and HAZ, respectively. Prenatal supplementation did not reduce the prevalence of growth faltering. Conclusions. Prenatal vitamin A supplementation had a small but significant effect on postnatal growth of children's length until 18 months of age compared with supplementation with either vitamin A + Zn or Zn alone, but not compared with placebo. It had no effects on other anthropometric measures and did not reduce the prevalence of growth faltering. Future studies should duplicate these findings before recommendations can be made. Copyright copyright The Authors 2011.
机译：目的。确定产前维生素A和/或锌的添加是否影响产后生长。设计。监测从出生到24个月大的儿童生长情况的随机对照试验的随访。设置。印度尼西亚中爪哇省。主题。母亲的孩子（ n 343）参加了妊娠期间补充维生素A和/或锌的双盲，随机对照研究。我们报告了产前补充对婴儿生长的影响，以年龄 Z 得分（WAZ），身高年龄 Z 得分（HAZ）衡量和身高体重 Z 分数（WHZ），从0到24个月不等，以及补充剂组之间生长缓慢的差异。结果。对于HAZ，仅维生素A和仅维生素A + Zn组在3个月和9个月时的绝对差分别为0.34 SD和0.37 SD，而仅维生素A和仅锌的组在18个月时的绝对差值为0.31 SD。与安慰剂相比，没有一种补品影响生长。将生长缓慢定义为两个或多个主要百分位线的向下交叉点，发现50-75％的儿童在9个月内生长缓慢，而17％和8％的WAZ和HAZ得分<-2 SD ， 分别。产前补充并未降低生长缓慢的患病率。结论。与补充维生素A + Zn或单独补充锌相比，补充维生素A对儿童直到18个月大的婴儿的身后生长具有很小但显着的影响，而与安慰剂相比则没有。它对其他人体测量学指标没有影响，也没有降低生长步履蹒跚的患病率。未来的研究应在提出建议之前复制这些发现。版权版权所有The Authors 2011。

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