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首页> 外文期刊>Psychopharmacology >The consequences of beer consumption in rats: acute anxiolytic and ataxic effects and withdrawal-induced anxiety.
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The consequences of beer consumption in rats: acute anxiolytic and ataxic effects and withdrawal-induced anxiety.

机译：大鼠饮啤酒的后果：急性抗焦虑和共济作用以及戒断引起的焦虑。

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RATIONALE. Rats avidly consume standard off-the-shelf beer; however, the behavioural consequences of beer consumption in rodents have hardly been studied. OBJECTIVES. The present study examined the acute anxiolytic and ataxic effects of beer consumption in rats and the anxiogenic effects of withdrawal from free access to beer. METHOD. In experiment 1, male Wistar rats received 30 min access to "near-beer" each day (a malt beverage that looks and tastes like beer but which contains <0.5% ethanol). On the test day, for some rats, ethanol (either 2% or 4% v/v) was added to the near-beer to make it resemble standard (ethanol-containing) beer of light rats were tested on their response to a predatory cue (a fabric collar that had been worn by a cat) and on an accelerating rotarod. In experiment 2, rats were trained in the same drinking paradigm as above and then tested on a further battery of anxiety tests. In experiment 3, rats were given continuous home cage access to either 4.5% beer or near-beer for 35 days. Half of the rats were then denied access to beer or near-beer for 24 h and then tested on the same anxiety test battery as in experiment 2. RESULTS. Rats drinking 4.5% beer approached a predatory cue significantly more than those given near-beer, indicating an anxiolytic effect. In experiment 2, rats drinking 4.5% beer displayed less anxiety-like behaviour in the elevated plus maze and emergence tests but not in the social interaction test. Rats given 4.5% beer fell off the rotarod significantly faster than rats given near-beer, indicating an ataxic effect. Rats previously given 4.5% beer drank significantly less near-beer the following day, suggesting a moderate aversion the day after beer consumption. In experiment 3, rats denied access to 4.5% beer showed significantly less social interaction and took longer to emerge into an open field than controls. CONCLUSION. These results are the first to our knowledge to show that rats will consume beer at levels that produce clear effects on anxiety and on motor co-ordination, and that will eventually produce behavioural signs of withdrawal.
机译：理据。大鼠狂热地饮用标准的现成啤酒。然而，几乎没有研究过在啮齿动物中食用啤酒的行为后果。目标本研究检查了大鼠食用啤酒的急性抗焦虑和共济作用以及从免费获取啤酒中退出所产生的焦虑作用。方法。在实验1中，雄性Wistar大鼠每天都会接受30分钟的“近啤酒”（一种麦芽饮料，其外观和味道类似于啤酒，但其中乙醇含量<0.5％）。在测试当天，对于一些大鼠，在近啤酒中添加了乙醇（2％或4％v / v）以使其类似于轻型大鼠的标准（含乙醇）啤酒，测试了它们对掠食性动物的反应提示（猫已经戴上的织物项圈）和加速的旋转脚架上。在实验2中，以与上述相同的饮酒范例对大鼠进行了训练，然后在另一组焦虑测试中对其进行了测试。在实验3中，连续35天给大鼠连续饲养笼子，使其获得4.5％啤酒或近啤酒。然后将一半的大鼠拒绝喝啤酒或近啤酒24小时，然后使用与实验2相同的焦虑测试电池进行测试。结果。喝4.5％啤酒的大鼠获得掠食性线索的次数明显多于近啤酒，这表明其具有抗焦虑作用。在实验2中，喝4.5％啤酒的大鼠在高架迷宫和脱发测试中表现出较少的焦虑样行为，而在社交互动测试中则没有。服用4.5％啤酒的老鼠从滚轮上掉下来的速度明显快于服用近啤酒的老鼠，这表明它具有共轭作用。先前服用4.5％啤酒的大鼠在第二天喝的啤酒少得多，这表明在饮用啤酒后的第二天有中等程度的反感。在实验3中，拒绝饮用4.5％啤酒的大鼠与对照组相比，社交互动明显减少，并且进入旷野的时间更长。结论。这些结果是我们所知的第一个结果，表明大鼠食用啤酒的水平会对焦虑和运动协调产生明显影响，并最终产生戒断的行为迹象。

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