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首页> 外文期刊>Psychopharmacology >Emotional valence and context of social influences on drug abuse-related behavior in animal models of social stress and prosocial interaction
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Emotional valence and context of social influences on drug abuse-related behavior in animal models of social stress and prosocial interaction

机译：社会压力和亲社会互动动物模型中与药物滥用相关行为相关的情绪价和社会影响背景

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Rationale: Social factors are important determinants of drug dependence and relapse. Objectives: We reviewed pre-clinical literature examining the role of social experiences from early life through the development of drug dependence and relapse, emphasizing two aspects of these experiences: (1) whether the social interaction is appetitive or aversive and (2) whether the social interaction occurs within or outside of the drug-taking context. Methods: The models reviewed include neonatal care, isolation, social defeat, chronic subordination, and prosocial interactions. We review results from these models in regard to effects on self-administration and conditioned place preference established with alcohol, psychostimulants, and opiates. Results: We suggest that in general, when the interactions occur outside of the drug-taking context, prosocial interactions are protective against drug abuse-related behaviors, whereas social stressors facilitate these behaviors. By contrast, positive or negative social interactions occurring within the drug-taking context may interact with other risk factors to enhance or inhibit these behaviors. Conclusions: Despite differences in the nature and complexity of human social behavior compared to other species, the evolving animal literature provides useful models for understanding social influences on drug abuse-related behavior that will allow for research on the behavioral and biological mechanisms involved. The models have contributed to understanding social influences on initiation and maintenance of drug use, but more research is needed to understand social influences on drug relapse.
机译：理由：社会因素是药物依赖和复发的重要决定因素。目的：我们回顾了临床前文献，研究了从早期生命到药物依赖和复发发展的社会经验的作用，强调了这些经验的两个方面：（1）社会互动是食欲还是厌恶，（2）社会互动发生在吸毒的背景之内或之外。方法：审查的模型包括新生儿护理，隔离，社交失败，慢性从属和亲社会互动。我们回顾了这些模型对自我管理的影响以及用酒精，精神刺激药和鸦片制剂建立的条件性场所偏爱的结果。结果：我们建议，总体而言，当互动发生在吸毒的背景之外时，亲社会互动可以防止与药物滥用相关的行为，而社交压力源则可以促进这些行为。相比之下，在吸毒情况下发生的正面或负面社会互动可能会与其他风险因素互动，以增强或抑制这些行为。结论：尽管与其他物种相比，人类社会行为的性质和复杂性有所不同，但不断发展的动物文献为理解社会对与药物滥用相关行为的影响提供了有用的模型，这将有助于研究所涉及的行为和生物学机制。这些模型有助于理解社会对药物使用的发起和维持的影响，但是需要更多的研究来了解社会对药物复发的影响。

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