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首页> 外文期刊>Progress in Neuro-Psychopharmacology & Biological Psychiatry: An International Research, Review and News Journal >Does work on obsessive-compulsive spectrum disorders contribute to understanding the heterogeneity of obsessive-compulsive disorder?
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Does work on obsessive-compulsive spectrum disorders contribute to understanding the heterogeneity of obsessive-compulsive disorder?

机译：强迫症谱系研究是否有助于理解强迫症的异质性？

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摘要

BACKGROUND: There is a growing literature on the concept of an obsessive-compulsive spectrum of disorders. Here, we consider the different dimensions on which obsessive-compulsive spectrum (OCSDs) lie, and focus on how the concepts from this literature may help understand the heterogeneity of obsessive-compulsive disorder (OCD). METHODS: A computerized literature search (MEDLINE: 1964-2005) was used to collect studies addressing different dimensions on which the OCSDs lie. Against this backdrop, we report on a cluster analysis of OCSDs within OCD. RESULTS: OCSDs may lie on several different dimensions. Our cluster analysis found that in OCD there were 3 clusters of OCD spectrum symptoms: (1) "Reward deficiency" (including trichotillomania, pathological gambling, hypersexual disorder and Tourette's disorder), (2) "Impulsivity" (including compulsive shopping, kleptomania, eating disorders, self-injury and intermittent explosive disorder), and (3) "Somatic" (including body dysmorphic disorder and hypochondriasis). CONCLUSIONS: It is unlikely that OC symptoms and disorders fall on any single phenomenological dimension; instead, multiple different constructs may be required to map this nosological space. Although there is evidence for the validity of some of the relevant dimensions, additional work is required to delineate more fully the endophenotypes that underlie OC symptoms and disorders.
机译：背景：关于强迫症的概念有越来越多的文献报道。在这里，我们考虑强迫症频谱（OCSD）所处的不同维度，并重点研究这些文献中的概念如何帮助理解强迫症（OCD）的异质性。方法：使用计算机文献检索（MEDLINE：1964-2005）收集针对OCSD所处的不同维度的研究。在此背景下，我们报告了OCD中对OCSD的聚类分析。结果：OCSD可能位于几个不同的维度上。我们的聚类分析发现，在强迫症中，强迫症的频谱症状有3种：（1）“奖励不足”（包括毛滴虫病，病理性赌博，性欲亢进症和图雷特氏症）;（2）“冲动性”（包括强迫性购物，kleptomania，饮食失调，自我伤害和间歇性爆炸失调），以及（3）“躯体”（包括身体畸形失调和软骨病）。结论：OC症状和失调不太可能出现在任何单一的现象学维度上。取而代之的是，可能需要多个不同的构造来映射此病态空间。尽管有证据表明某些相关维度的有效性，但仍需要进行其他工作才能更全面地描述OC症状和失调的内在表型。

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