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首页> 外文期刊>Psychopharmacology >The pharmacological sensitivity of a touchscreen-based visual discrimination task in the rat using simple and perceptually challenging stimuli
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The pharmacological sensitivity of a touchscreen-based visual discrimination task in the rat using simple and perceptually challenging stimuli

机译：基于触摸屏的视觉识别任务在大鼠中的药理敏感性，使用简单且具有感知挑战性的刺激

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Rationale: Cognitive testing with touchscreen-equipped operant boxes ('touchscreens') is becoming increasingly popular. Tasks, such as paired associate learning or reversal learning of visual stimuli, have the discrimination of visual stimuli as a fundamental component. However, the effect of drugs commonly used in the study of cognitive mechanisms has yet to be described in a visual discrimination. Objective: The objective of the study was to profile a range of psychoactive agents (glutamatergic, dopaminergic, and cholinergic agonists and antagonists) known to be important in cognitive processing on visual discrimination performance using a touch sensitive computer monitor. Methods: Male Lister Hooded rats were trained to a stable level of performance in a simple visual discrimination. In Experiment 1, the effect of MK-801, phencyclidine, memantine, dextroamphetamine sulphate (d-amphetamine) and scopolamine was assessed. In Experiment 2, the stimuli were blended together resulting in a perceptually more demanding discrimination and a reduction in accuracy. The rats used in Experiment 1 were then retested with these 'morphed' stimuli under the influence of the above compounds. Results: MK-801, PCP, and d-amphetamine induced selective deficits in accuracy in both versions of the task. In contrast, scopolamine and memantine produced non-selective deficits in accuracy. Morphing the stimuli reduced accuracy, but did not alter the observed behavioural profile after compound administration. Conclusion: These data improve our understanding of the basic neuropharmacology of a visual discrimination in cognitive tests employing touchscreens and will aid in the interpretation of pharmacological studies with more cognitively demanding methodologies.
机译：基本原理：带有触摸屏的操作盒（“触摸屏”）的认知测试变得越来越流行。诸如视觉视觉刺激的配对联想学习或逆向学习之类的任务，以视觉刺激的辨别为基本组成部分。但是，在认知机制研究中通常使用的药物的效果尚未在视觉辨别中描述。目的：该研究的目的是使用触摸感应式计算机显示器，对已知对视觉识别性能认知处理中重要的一系列精神活性剂（谷氨酸能，多巴胺能和胆碱能激动剂和拮抗剂）进行分析。方法：训练简单的视觉辨认力使雄性李斯特连帽雄性大鼠训练到稳定的表现水平。在实验1中，评估了MK-801，苯环利定，美金刚，硫酸右旋苯丙胺（d-苯异丙胺）和东碱的作用。在实验2中，将刺激混合在一起，导致感觉上要求更高的辨别力和准确性降低。然后在上述化合物的作用下，用这些“变形”刺激物对实验1中使用的大鼠进行重新测试。结果：MK-801，PCP和d-苯异丙胺在两种版本的任务中均导致选择性选择性缺陷。相反，东pol碱和美金刚在准确性上产生非选择性的缺陷。使刺激变形会降低准确性，但在化合物给药后不会改变观察到的行为特征。结论：这些数据改善了我们对采用触摸屏的认知测试中视觉辨别的基本神经药理学的理解，并将有助于以更具认知要求的方法解释药理学研究。

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