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首页> 外文期刊>Progress in Neuro-Psychopharmacology & Biological Psychiatry: An International Research, Review and News Journal >Switching antipsychotics: Imaging the differential effect on the topography of postsynaptic density transcripts in antipsychotic-naive vs. antipsychotic-exposed rats
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Switching antipsychotics: Imaging the differential effect on the topography of postsynaptic density transcripts in antipsychotic-naive vs. antipsychotic-exposed rats

机译：转换抗精神病药物：对未接受过抗精神病药物的大鼠与抗精神病药物接触的大鼠，对突触后密度转录物的形貌差异进行成像

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The postsynaptic density (PSD) has been regarded as a functional switchboard at the crossroads of a dopamine-glutamate interaction, and it is putatively involved in the pathophysiology of psychosis. Indeed, it has been demonstrated that antipsychotics may modulate several PSD transcripts, such as PSD-95, Shank, and Homer. Despite switching antipsychotics is a frequent strategy to counteract lack of efficacy and/or side effect onset in clinical practice, no information is available on the effects of sequential treatments with different antipsychotics on PSD molecules. The aim of this study was to evaluate whether a previous exposure to a typical antipsychotic and a switch to an atypical one may affect the expression of PSD transcripts, in order to evaluate potential neurobiological correlates of this common clinical practice, with specific regards to putative synaptic plasticity processes.
机译：突触后密度（PSD）被认为是多巴胺-谷氨酸相互作用的十字路口上的功能开关，它被认为与精神病的病理生理有关。确实，已经证明抗精神病药可以调节几种PSD转录本，例如PSD-95，Shank和Homer。尽管切换抗精神病药是抵消临床实践中缺乏功效和/或副作用发作的常见策略，但是尚无关于使用不同抗精神病药对PSD分子进行序贯治疗的信息。这项研究的目的是评估以前接触典型的抗精神病药和改用非典型药物是否会影响PSD转录物的表达，从而评估这一常见临床实践的潜在神经生物学相关性，并特别考虑假定的突触。可塑性过程。

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