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首页> 外文期刊>Progress in Neuro-Psychopharmacology & Biological Psychiatry: An International Research, Review and News Journal >Adjunctive treatment with low-dosage aripiprazole for blonanserin-induced hyperprolactinemia in a female patient with schizophrenia.
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Adjunctive treatment with low-dosage aripiprazole for blonanserin-induced hyperprolactinemia in a female patient with schizophrenia.

机译：低剂量阿立哌唑用于女性精神分裂症患者的布兰瑟林诱导的高泌乳素血症的辅助治疗。

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摘要

Hyperprolactinemia, which is induced by antipsychotic treatment through the dopaminergic blockade, causes amenorrhea, infertility, and galactorrhea (Johnsen et al., 2008). Recently, aripiprazole has been widely reported as effective for the treatment of antipsychotic-induced hyperprolactinemia because of its partial agonistic actions to dopamine D2 receptor with high affinity (Byerly et al, 2009; Chen et al, 2008, 2009; Rainka et al, 2009; Saitis et al, 2008; Kane et al, 2009). However, in all cases, therapeutic gain of adjunctive aripiprazole in the treatment of hyperprolactinemia was evaluated only during one week with high dosage greater than 10 mg/day.We report the case of a 32-year-old female patient with schizophrenia who showed blonanserin-induced hyperprolactinemia through the potent (high affinity) dopamine D(2) antagonist properties. Her serum prolactin level declined rapidly during 12h and normalized within five days by adjunctive low-dosage aripiprazole treatment.
机译：高催乳素血症是通过多巴胺能阻滞剂进行抗精神病药物治疗而引起的，会引起闭经，不育和溢乳（Johnsen等，2008）。近来，由于阿立哌唑对多巴胺D2受体具有高亲和力，因此具有部分激动作用，因此已广泛报道阿立哌唑可有效治疗抗精神病药物引起的高泌乳素血症（Byerly等，2009; Chen等，2008,2009; Rainka等，2009 ; Saitis等，2008; Kane等，2009）。但是，在所有情况下，仅在超过10 mg /天的高剂量下，仅在一周内评估了阿立哌唑辅助治疗高泌乳素血症的治疗效果。我们报道了一名32岁女性精神分裂症患者出现blonanserin的情况。通过有效的（高亲和力）多巴胺D（2）拮抗剂特性诱导高泌乳素血症。她的血清催乳素水平在12小时内迅速下降，并在5天内通过辅助低剂量阿立哌唑治疗而恢复正常。

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