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首页> 外文期刊>Pure and Applied Chemistry >Cerium in human milk samples and its transfer from blood to milk: Is there an elevated nutritional risk for breast-fed babies?
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Cerium in human milk samples and its transfer from blood to milk: Is there an elevated nutritional risk for breast-fed babies?

机译：人乳样品中的铈及其从血液向牛奶的转移：母乳喂养婴儿的营养风险是否增加？

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The general population is increasingly exposed to cerium (Ce), which is contained in industrial products or is present as nuclear Ce fission products. Some studies suggested a link between elevated Ce levels and endomyocardial fibrosis. Since breast milk is the optimal, and directly after birth, usually the sole nutrition for newborns, exposure of females to Ce and its transfer to infants by breast-feeding is of concern in neonate protection. Consequently, the transfer rate of Ce from blood to breast milk is of interest for elucidating the Ce exposure of infants. Biomonitoring of paired serum and breast milk samples provides such information about Ce transfer to human milk. Therefore, this study is aimed at clarification of the relationship between Ce in human milk and serum from respective mothers for elucidating Ce enrichment in human milk with possible nutritional risk for newborns. As a prerequisite a strictly quality-controlled Ce determination method applicable to very low Ce concentration was developed, and its figures of merit were determined and found to be sufficient for our purpose. It turned out that Ce concentration in milk from Munich (Germany) and Madrid (Spain) showed a median of 13 ng/L. Ce concentrations in serum were at limit of quantification (LOQ) 10 ng/L (Munich) or 21.6-70.3 ng/L (Madrid), suggesting a higher Ce intake in Madrid. No enrichment from blood to milk was seen, and no elevated nutritional risk for breast-fed babies from Ce was found. Ce in serum, but not in milk, could indicate environmental Ce.
机译：普通人群越来越多地接触铈（Ce），铈是工业产品中所含的或作为核Ce裂变产品而存在的。一些研究表明铈水平升高与心肌内膜纤维化之间存在联系。由于母乳是最佳的，并且在刚出生后通常是新生儿的唯一营养，因此母乳接触女性以及通过母乳喂养将母乳转移到婴儿中是新生儿保护的关注点。因此，Ce从血液向母乳的转移速率对于阐明婴儿的Ce暴露很重要。对配对的血清和母乳样品进行生物监测可提供有关Ce转移至母乳的信息。因此，本研究旨在阐明人乳中的Ce与来自各个母亲的血清之间的关系，以阐明人乳中Ce的富集以及新生儿可能的营养风险。作为前提，开发了适用于极低Ce浓度的严格质量控制的Ce测定方法，并确定了其品质因数，足以满足我们的目的。事实证明，来自慕尼黑（德国）和马德里（西班牙）的牛奶中铈的浓度中位数为13 ng / L。血清中的Ce浓度处于定量极限（LOQ）10 ng / L（慕尼黑）或21.6-70.3 ng / L（马德里），表明马德里的Ce摄入量较高。没有发现从血液到牛奶的浓缩，也没有发现Ce母乳喂养婴儿的营养风险升高。血清中的铈，而不是牛奶中的铈，可能表明环境中的铈。

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