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首页> 外文期刊>Pulmonary pharmacology & therapeutics >Effects of glucocorticoids on the neutrophil count: a cohort study among hospitalized patients.
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Effects of glucocorticoids on the neutrophil count: a cohort study among hospitalized patients.

机译：糖皮质激素对中性粒细胞计数的影响：一项住院患者的队列研究。

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BACKGROUND: Systemic glucocorticoids are often used in clinical practice for a large variety of indications. Clinical observations have shown that patients using glucocorticoids often have higher neutrophil counts. Debate remains whether this observed neutrophilia is associated with glucocorticoid use or that other factors, like disease and severity of disease, should be considered. The objective of this study was to investigate the effect of systemic glucocorticoids on the absolute neutrophil count in hospitalized patients. METHODS: A cohort study was conducted using data from the Utrecht Patient Oriented Database which comprises clinical data of patients of the University Medical Center Utrecht. We identified all adult patients, hospitalized in 2005 with at least two blood samples for hematological testing during admission and compared in-hospital glucocorticoid use with non-use. RESULTS: A total of 809 glucocorticoid users and 2658 non-users were included in the study with comparable neutrophil counts at admission (8.2.10(9)/l for glucocorticoid users and 8.0.10(9)/l for non-users). Overall analysis showed a slight association between glucocorticoid use and an increase in neutrophil count (RR 1.3; 95% CI 1.1-1.5). However, within diagnostic subgroups there was no increase in neutrophil count in glucocorticoid users. Furthermore, among all no dose response relationship, no effect of time between the two samples, and no effect of anti-inflammatory/sodium retaining potency was found. CONCLUSION: Observed neutrophilia in users of systemic glucocorticoids is probably associated with underlying disease, rather than glucocorticoid use itself.
机译：背景：全身性糖皮质激素通常在临床实践中用于多种适应症。临床观察表明，使用糖皮质激素的患者中性粒细胞数量通常较高。是否观察到这种嗜中性白血球增多症与糖皮质激素的使用有关，还是应考虑其他因素，例如疾病和疾病的严重程度，仍然存在争议。本研究的目的是研究全身性糖皮质激素对住院患者中性粒细胞绝对计数的影响。方法：使用来自乌得勒支患者导向数据库的数据进行了一项队列研究，其中包括乌得勒支大学医学中心患者的临床数据。我们确定了所有成年患者，他们于2005年入院，至少入院时进行了两次血液样本血液学检查，并将住院期间使用糖皮质激素与未使用糖皮质激素进行了比较。结果：总共809位糖皮质激素使用者和2658位非使用者被纳入研究，入院时中性粒细胞计数相当（糖皮质激素使用者为8.2.10（9）/ l，非使用者为8.0.10（9）/ l） 。总体分析显示，糖皮质激素的使用与中性粒细胞计数的增加之间存在轻微关联（RR 1.3; 95％CI 1.1-1.5）。但是，在诊断亚组中，糖皮质激素使用者的中性粒细胞计数没有增加。此外，在所有没有剂量反应关系的情况下，在两个样品之间没有时间影响，也没有发现抗炎/钠保持力的影响。结论：全身性糖皮质激素使用者的嗜中性粒细胞增多可能与潜在疾病有关，而不是糖皮质激素的使用本身。

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