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首页> 外文期刊>Pulmonary pharmacology & therapeutics >Upregulation of stromal cell derived factor-1alpha in collagen vascular diseases-associated interstitial pneumonias (CVDs-IPs).
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Upregulation of stromal cell derived factor-1alpha in collagen vascular diseases-associated interstitial pneumonias (CVDs-IPs).

机译：胶原血管疾病相关的间质性肺炎（CVDs-IPs）中基质细胞衍生因子1α的上调。

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OBJECTIVE: We speculated that distinct angiogenic profiles are involved in idiopathic interstitial pneumonias (IIPs) in comparison with interstitial pneumonias associated with collagen vascular disease (CVD-IPs). This hypothesis was investigated by measuring the expression of a cardinal biologic axis, the vascular endothelial growth factor (VEGF)-stromal derived growth factor [SDF-1alpha, transcripts 1 and 2 (TR1 and TR2)] and receptor, CXCR4 and the angiogenetic receptors CXCR2 and CXCR3 in bronchoalveolar lavage fluid (BALF) in both conditions. METHODS: We studied prospectively 25 patients with fibrotic IIPs (f-IIPs) [20 with idiopathic pulmonary fibrosis (IPF) and 5 with idiopathic non-specific interstitial pneumonia (NSIP)] and 16 patients with CVD-IPs. mRNA expression was measured by Real-Time RT-PCR and protein was evaluated by Western Blotting. RESULTS: A significantly greater value has been detected in SDF-1alpha-TR1 mRNA expression levels of CVD-IPs (p=0.05) in comparison with IPF group. A similar trend has been also detected in protein expression in favor of CVD-IP group. In addition, VEGF mRNA levels have been found significantly increased in CVD-IPs in comparison with the NSIP group (p=0.05). No significant difference has been found in SDF-1alpha-TR2-CXCR4 mRNA and CXCR2-CXCR3 between the two groups. CONCLUSION: These results showed increased expression of SDF-1alpha in CVD-IPs, suggesting different angiogenic procedures. Further studies are needed in order to better explore the angiogenetic pathway in these disorders.
机译：目的：我们推测与胶原性血管疾病（CVD-IPs）相关的间质性肺炎相比，特发性间质性肺炎（IIP）涉及不同的血管生成特性。通过测量基本生物学轴，血管内皮生长因子（VEGF）-基质衍生生长因子[SDF-1alpha，转录本1和2（TR1和TR2）]和受体，CXCR4和血管生成受体的表达来研究该假设在两种情况下，支气管肺泡灌洗液（BALF）中的CXCR2和CXCR3。方法：我们前瞻性研究了25例纤维化IIP（f-IIP）患者[20例特发性肺纤维化（IPF）和5例特发性非特异性间质性肺炎（NSIP）]和16例CVD-IPs。通过实时RT-PCR测量mRNA表达，并通过蛋白质印迹法评估蛋白质。结果：与IPF组相比，CVD-IPs的SDF-1alpha-TR1 mRNA表达水平显着更高（p = 0.05）。在蛋白质表达中也发现了类似的趋势，有利于CVD-IP组。此外，与NSIP组相比，已发现CVD-IPs中的VEGF mRNA水平显着增加（p = 0.05）。两组之间在SDF-1alpha-TR2-CXCR4 mRNA和CXCR2-CXCR3中没有发现显着差异。结论：这些结果表明SDF-1α在CVD-IPs中表达增加，提示不同的血管生成程序。为了更好地探索这些疾病中的血管生成途径，需要进一步的研究。

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