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Is a one-night stay in the lab really enough to conclude? First-night effect and night-to-night variability in polysomnographic recordings among different clinical population samples

机译:在实验室呆一晚真的足够结论吗?不同临床人群样本在多导睡眠图记录中的首夜效应和夜间变化

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摘要

While polysomnography remains the current gold standard in sleep investigation, guidelines for single night versus consecutive recordings in a sleep laboratory have been disputed mainly because of two phenomena: the first-night effect and night-to-night variability. One hundred and twenty nine subjects, that underwent two consecutive nights of polysomnographic recording in a general University Hospital's sleep lab, were divided into four groups: sleep-related breathing disorders (SRBD), insomnia, movement and behavioral disorders and a healthy control (HC) group based on their complaints at admission and sleep study results. Sleep parameters of both consecutive two nights were compared and analyzed. All groups showed a significant first-night effect. However the latter seemed more pronounced in the insomnia group. Furthermore, a clinically significant intra-patient night-to-night variability was found for the apnea-hypopnea index in the SRBD-group. Due to the observed first-night effect among any subject group and the potential impact of night-to-night variability of the apnea-hypopnea index, we conclude that the clinical assessment of sleep disorders should be similar in every patient. Hence, the present study underlines the importance of two consecutive nights of polysomnographic recording as a potential reference standard for the execution of sleep investigations.
机译:尽管多导睡眠监测仪仍是睡眠研究的当前金标准,但对于睡眠实验室中单夜与连续记录的指导原则却存在争议,主要是因为有两种现象:第一夜效应和夜夜差异。在一家综合性大学医院的睡眠实验室中连续进行了两个晚上多导睡眠图记录的129名受试者分为四组:与睡眠有关的呼吸障碍(SRBD),失眠,运动和行为障碍以及健康对照(HC) )根据入院时的抱怨和睡眠研究结果进行分组。比较并分析了连续两个晚上的睡眠参数。所有组均显示出明显的第一夜效果。但是,后者在失眠组中似乎更为明显。此外,在SRBD组中发现了临床上有意义的患者夜间至夜间夜间呼吸变异性。由于在任何受试者组中观察到的第一夜效应以及呼吸暂停低通气指数夜间变化的潜在影响,我们得出结论,每位患者的睡眠障碍临床评估应相似。因此,本研究强调了连续两个晚上的多导睡眠图记录作为进行睡眠调查的潜在参考标准的重要性。

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