• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Psychiatry Research. Neuroimaging >Modulation of fronto-limbic activity by the psychoeducation in euthymic bipolar patients. A functional MRI study
【24h】

Modulation of fronto-limbic activity by the psychoeducation in euthymic bipolar patients. A functional MRI study

机译：在正常人双相情感障碍患者中通过心理教育调节额-边缘活动。功能性MRI研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Bipolar disorders (BD) are mainly characterized by emotional and cognitive processing impairment. The cerebral substrate explaining BD impairment and the action mechanisms of therapies are not completely understood, especially for psychosocial interventions. This fMRI study aims at assessing cerebral correlates of euthymic bipolar patients (EBP) before and after psychoeducation therapy. Sixteen EBP and 16 matched healthy subjects (HS) performed a word-face emotional Stroop task in two separate fMRI sessions at 3-month interval. Between fMRI sessions, EBP underwent psychoeducation. Before psychoeducation, the comparison of EBP vs. HS in fMRI data revealed (a) significant decreased activity of cognitive control regions such as bilateral inferior and left superior frontal gyri, right insula, right fusiform gyrus and bilateral occipital gyri and (b) significant increased activity of emotion-related processing regions such as bilateral hippocampus, parahippocampal gyri and the left middle temporal gyrus. After psychoeducation, EBP showed significant clinical improvement, increased activity of inferior frontal gyri and a tendency toward decreased activity of right hippocampus and parahippocampal gyrus. These results suggest that the imbalance between cognitive control and emotion processing systems characterizing BD acute episodes may persist during euthymic periods. Moreover, this imbalance may be improved by psychoeducation, which enhances the cognitive control and modulates emotional fluctuations in EBP.
机译：躁郁症（BD）的主要特征是情绪和认知加工障碍。解释BD损伤的脑底物和疗法的作用机制尚不完全清楚，特别是对于社会心理干预而言。这项功能磁共振成像研究旨在评估心理教育治疗前后的正常人双相情感障碍患者（EBP）的大脑相关性。 16名EBP和16名匹配的健康受试者（HS）在两个独立的fMRI会话中以3个月的间隔执行了词面情感Stroop任务。在功能磁共振成像检查之间，对EBP进行了心理教育。在进行心理教育之前，在功能磁共振成像数据中对EBP和HS进行比较后发现：（a）认知控制区（如双侧下和左上额回，右岛，右梭状回和双枕后回）的活动明显降低，（b）显着增加与情绪有关的加工区域的活动，如双侧海马，海马旁回和左颞中回。经心理教育后，EBP表现出显着的临床改善，额下回活动增加，右海马和海马旁回活动减少。这些结果表明，在正常个体时期，以BD急性发作为特征的认知控制和情绪处理系统之间的不平衡可能会持续存在。此外，可以通过心理教育来改善这种不平衡，这可以增强认知控制并调节EBP中的情绪波动。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号