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首页> 外文期刊>Psychiatry Research. Neuroimaging >Reduced language lateralization in first-episode schizophrenia: An fMRI index of functional asymmetry
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Reduced language lateralization in first-episode schizophrenia: An fMRI index of functional asymmetry

机译：减少首发精神分裂症的语言偏侧化：功能不对称的fMRI指数

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摘要

Patients with schizophrenia exhibit a decrease or loss of normal anatomical brain asymmetry that also extends to functional levels. We applied functional magnetic resonance imaging (fMRI) to investigate language lateralization in patients with schizophrenia during their first episode of illness, thus excluding effects of chronic illness and treatment. Brain regions activated during language tasks of verb generation and passive music listening were explored in 12 first-episode patients with schizophrenia and 17 healthy controls. Regions of interest corresponded to Broca's area in the inferior frontal gyrus (IFG) and Wernicke's area in the superior temporal sulcus (STS). Patients with schizophrenia had significantly smaller lateralization indices in language-related regions than controls. A similar effect was observed in their IFG and STS regions. There was no difference between the groups in the auditory cortex for the music task. Patients with schizophrenia demonstrated greater activation than the controls in temporal regions: the difference was larger in patients with more severe positive symptom subscores. In conclusion, patients with schizophrenia demonstrated loss of normal functional brain asymmetry, as reflected in diminished lateralization of language-related activation in frontal and temporal regions. This phenomenon was already present during their first episode of psychosis, possibly reflecting developmental brain abnormalities of the illness.
机译：精神分裂症患者表现出正常解剖脑不对称性的减少或丧失，也扩展到功能水平。我们应用功能磁共振成像（fMRI）来研究精神分裂症患者在首次发作期间的语言偏侧性，从而排除了慢性疾病和治疗的影响。在12例精神分裂症首发患者和17例健康对照者中，探索了在动词生成和被动听音乐的语言任务中激活的大脑区域。感兴趣的区域对应于额下回（IFG）中的布罗卡区和颞上沟（STS）中的韦尼克（Wernicke）区。精神分裂症患者在语言相关区域的偏侧化指数明显小于对照组。在其IFG和STS区域观察到了类似的效果。在听觉皮层中，音乐任务的各组之间没有差异。精神分裂症患者在颞部区域的活动度高于对照组：症状阳性分数更高的患者差异更大。总之，精神分裂症患者表现出正常的功能性大脑不对称性丧失，这反映在额叶和颞叶区域与语言相关的激活的侧向化程度降低。这种现象在他们的第一次精神病发作时就已经存在，可能反映出该病的大脑发育异常。

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