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首页> 外文期刊>Psychiatry Research. Neuroimaging >Readiness to change and brain damage in patients with chronic alcoholism
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Readiness to change and brain damage in patients with chronic alcoholism

机译：慢性酒精中毒患者的变化准备和脑损伤

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High motivation to change is a crucial triggering factor to patients' engagement in clinical treatment. This study investigates whether the low readiness to change observed in some alcoholic inpatients at treatment entry could, at least partially, be linked with macrostructural gray matter abnormalities in critical brain regions. Participants comprised 31 alcoholic patients and 27 controls, who underwent 1.5-T magnetic resonance imaging. The Readiness to Change Questionnaire, designed to assess three stages of motivation to change (precontemplation, contemplation and action stages), was completed by all patients, who were then divided into "Action" (i.e. patients in action stage) and "PreAction" (i.e. patients in precontemplation or in contemplation stage) subgroups. The PreAction subgroup, but not the Action subgroup, had gray matter volume deficits compared with controls. Unlike the patients in the Action subgroup, the PreAction patients had gray matter abnormalities in the cerebellum (Crus I), fusiform gyri and frontal cortex. The low level of motivation to modify drinking behavior observed in some alcoholic patients at treatment entry may be related to macrostructural brain abnormalities in regions subtending cognitive, emotional and social abilities. These brain volume deficits may result in impairment of critical abilities such as decision making, executive functions and social cognition skills. Those abilities may be needed to resolve ambivalence toward alcohol addiction and to apply "processes of change", which are essential for activating the desire to change problematic behavior.
机译：改变的强烈动机是患者参与临床治疗的关键触发因素。这项研究调查了某些酒精性住院患者在接受治疗时观察到的改变准备不足的现象是​​否至少部分与关键脑区的宏观结构灰质异常有关。参加者包括31名酒精中毒患者和27名对照，他们接受了1.5-T磁共振成像。所有患者均完成了“改变准备就绪调查表”，旨在评估改变动机的三个阶段（预沉思，沉思和行动阶段），然后将其分为“行动”（即处于行动阶段的患者）和“预行动”（例如，处于预想或预想阶段的患者）。与对照组相比，PreAction分组而不是Action分组具有灰质体积不足。与Action亚组的患者不同，PreAction患者在小脑（Crus I），梭状回和额叶皮层有灰质异常。在某些酒瘾患者进入治疗时观察到的改变饮酒行为的低水平动机可能与在认知，情感和社交能力对立区域的大脑宏观结构异常有关。这些大脑容量不足可能会导致诸如决策，执行功能和社交认知技能等关键能力受损。可能需要这些能力来解决对酒精成瘾的矛盾情绪，并应用“改变过程”，这对于激发改变有问题行为的愿望至关重要。

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