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首页> 外文期刊>Psychiatry Research. Neuroimaging >Prefrontal dysfunction in remitted depression at work reinstatement using near-infrared spectroscopy
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Prefrontal dysfunction in remitted depression at work reinstatement using near-infrared spectroscopy

机译：使用近红外光谱技术恢复工作时缓解的抑郁症中的前额叶功能障碍

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摘要

A long-term and/or recurrent sickness absence from work due to depression has been an important health problem in industrial countries. In addition, previous sick leave is a risk factor of recurrence. However, many characteristics, especially biological aspects, have not been investigated in remitted depressive patients who were ready to return to work from sickness absence. Therefore, the purpose of this study is to clarify the pathophysiological characteristics of patients who were at risk for recurrence of sickness absence. We recruited 21 patients and 16 healthy control subjects. All patients were ready to return to work within one month from long-term sickness absence. All subjects were examined for prefrontal function represented by oxyHb changes during the verbal fluency task (VFT) and the Stroop task using near-infrared spectroscopy. Suppressed prefrontal reaction during the VFT and increased prefrontal reaction during the Stroop task were observed in the patient group compared with the control group. Significantly lengthened reaction time was observed in the incongruent condition in the patient group during the Stroop task. Depressive patients showed impaired executive function measured by the Stroop task and had prefrontal dysfunction despite clinical remission. Residual prefrontal dysfunction may be one biological reason for repetitive sickness absence.
机译：在工业化国家，由于抑郁而长期和/或反复缺勤一直是重要的健康问题。此外，以前的病假是复发的危险因素。然而，尚未缓解的缓解抑郁症患者的许多特征，尤其是生物学方面的特征，这些患者准备从缺病后恢复工作。因此，本研究的目的是阐明有疾病复发风险的患者的病理生理特征。我们招募了21名患者和16名健康对照受试者。所有患者都可以在长期病假后一个月内恢复工作。使用近红外光谱法检查了所有受试者的言语流畅性任务（VFT）和Stroop任务中oxyHb变化所代表的前额叶功能。与对照组相比，患者组观察到了VFT期间前额叶反应的抑制和Stroop任务期间前额叶反应的增加。在Stroop任务期间，在患者组不一致的情况下，观察到明显延长的反应时间。抑郁症患者通过Stroop任务测得的执行功能受损，尽管临床缓解但仍存在额前功能障碍。残留的额叶前功能障碍可能是重复性疾病缺乏的生物学原因之一。

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