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首页> 外文期刊>Psychiatry Research. Neuroimaging >Prefrontal grey and white matter neurometabolite changes after atomoxetine and methylphenidate in children with attention deficit/hyperactivity disorder: A 1H magnetic resonance spectroscopy study
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Prefrontal grey and white matter neurometabolite changes after atomoxetine and methylphenidate in children with attention deficit/hyperactivity disorder: A 1H magnetic resonance spectroscopy study

机译：注意缺陷/多动障碍患儿阿托西汀和哌醋甲酯后前额叶灰白质神经代谢产物的变化：一项1H磁共振波谱研究

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Attention deficit/hyperactivity disorder (ADHD) is the most common neurobehavioral childhood disorder. Dysfunction of prefrontal neural circuits which are responsible for executive and attentional functions has been previously shown in ADHD. We investigated the neurometablite changes in areas included in dorsolateral prefrontal neural circuits after 2 months of long-acting methylphenidate or atomoxetine medication in children with ADHD who were responders to treatment. Twenty-one ADHD children were examined by single voxel 1H-magnetic resonance spectroscopy (MRS) before and after 2 months of medication with OROS methylphenidate (n=10) or atomoxetine (n=11). The spectra were taken from the dorsolateral prefrontal cortex (DLPFC, 8ml) and white matter behind the DLPFC (anterior semioval center, 7.5ml), bilaterally. NAA and NAA/Cr (N-acetylaspartate/creatine) decreased in the left DLPFC and Cho/Cr (choline/creatine) increased in the right DLPFC after atomoxetine medication. Glu+Gln and Glu+Gln/Cr (glutamate/glutamine) increased in the left white matter after methylphenidate medication. We hypothesize that atomoxetine could decrease hyperactivation of DLPFC neurons and methylphenidate could lead to increased activation of cortical glutamatergic projections with the consequences of increased tonic dopamine release in the mesocortical system.
机译：注意缺陷多动障碍（ADHD）是最常见的儿童神经行为。先前已在ADHD中显示了负责执行和注意功能的前额神经回路功能障碍。我们调查了对治疗有反应的多动症儿童长效哌醋甲酯或阿托西汀治疗2个月后，背外侧前额神经回路区域神经代谢的变化。在用OROS哌醋甲酯（n = 10）或阿托西汀（n = 11）服药2个月之前和之后，通过单体素1H磁共振波谱（MRS）检查了21名ADHD儿童。光谱从两侧的背外侧前额叶皮层（DLPFC，8ml）和DLPFC后的白质（前半卵形中心，7.5ml）获取。接受阿托西汀治疗后，左DLPFC中的NAA和NAA / Cr（N-乙酰天门冬氨酸/肌酸）降低，而右DLPFC中的Cho / Cr（胆碱/肌酸）升高。哌醋甲酯治疗后左白质中的Glu + Gln和Glu + Gln / Cr（谷氨酸/谷氨酰胺）增加。我们假设阿托西汀可降低DLPFC神经元的过度活化，而哌醋甲酯可导致皮质谷氨酸能投射的活化增加，并导致中皮层系统中补品多巴胺释放增加。

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