• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Psychiatry Research. Neuroimaging >Neural correlates of visuospatial working memory in attention-deficit/hyperactivity disorder and healthy controls
【24h】

Neural correlates of visuospatial working memory in attention-deficit/hyperactivity disorder and healthy controls

机译：注意缺陷/多动障碍和健康对照者的视觉空间工作记忆的神经相关性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Impaired visuospatial working memory (VSWM) is suggested to be a core neurocognitive deficit in attention-deficit/hyperactivity disorder (ADHD), yet the underlying neural activation patterns are poorly understood. Furthermore, it is unclear to what extent age and gender effects may play a role in VSWMrelated brain abnormalities in ADHD. Functional magnetic resonance imaging (FMRI) data were collected from 109 individuals with ADHD (GOT male) and 103 controls (53% male), aged 8-25 years, during a spatial span working memory task. VSWM-related brain activation was found in a widespread network, which was more widespread compared with N-back tasks used in the previous literature. Higher brain activation was associated with higher age and male gender. In comparison with controls, individuals with ADHD showed greater activation in the left inferior frontal gyrus (IFG) and the lateral frontal pole during memory load increase, effects explained by reduced activation on the low memory load in the IFG pars triangularis and increased activation during high load in the IFG pars opercularis. Age and gender effects did not differ between controls and individuals with ADHD. Results indicate that individuals with ADHD have difficulty in efficiently and sufficiently recruiting left inferior frontal brain regions with increasing task difficulty. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
机译：视觉空间工作记忆障碍（VSWM）被认为是注意力缺乏/多动障碍（ADHD）的核心神经认知缺陷，但对潜在的神经激活模式知之甚少。此外，尚不清楚年龄和性别影响在多动症中与VSWM相关的脑异常中起何种程度的作用。功能性磁共振成像（FMRI）数据是在空间跨度工作记忆任务中从109位ADHD（GOT男性）个体和103位对照（53％男性）（年龄在8-25岁之间）收集的。在广泛的网络中发现了VSWM相关的大脑激活，该网络与以前文献中使用的N-back任务相比更为广泛。较高的大脑激活与较高的年龄和男性性别有关。与对照组相比，多动症患者在记忆负荷增加时，左下额回（IFG）和外侧额叶的激活程度更高，其影响可以通过降低对三角肌IFG低记忆负荷的激活和在高负荷时的激活增加来解释。加载IFG pars opercularis。对照组和ADHD患者的年龄和性别影响没有差异。结果表明，多动症患者难以有效，充分地募集左下额叶大脑区域，而任务难度却越来越大。 （C）2015 Elsevier Ireland Ltd.保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号