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An MRI-based approach for the measurement of the dorsolateral prefrontal cortex in humans

机译：基于MRI的人体背外侧前额叶皮层测量方法

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摘要

The dorsolateral prefrontal cortex (DLPFC) has been implicated in the pathophysiology of mental disorders. Previous region-of-interest MRI studies that attempted to delineate this region adopted various landmarks and measurement techniques, with inconsistent results. We developed a new region-of-interest measurement method to obtain morphometric data of this region from structural MRI scans, taking into account knowledge from cytoarchitectonic postmortem studies and the large inter-individual variability of this region. MRI scans of 10 subjects were obtained, and DLPFC tracing was performed in the coronal plane by two independent raters using the semi-automated software Brains2. The intra-class correlation coefficients between two independent raters were 0.94 for the left DLPFC and 0.93 for the right DLPFC. The mean ± S.D. DLPFC volumes were 9.23 ± 2.35 ml for the left hemisphere and 8.20 ± 2.08 ml for the right hemisphere. Our proposed method has high inter-rater reliability and is easy to implement, permitting the standardized measurement of this region for clinical research applications.
机译：背外侧前额叶皮层（DLPFC）已牵涉到精神障碍的病理生理。先前试图勾画该区域的感兴趣区域MRI研究采用了各种界标和测量技术，但结果却不一致。我们开发了一种新的感兴趣区域测量方法，以从结构MRI扫描中获得该区域的形态计量学数据，同时考虑到细胞建筑师尸检研究的知识以及该区域的较大个体差异。进行了10位受试者的MRI扫描，并使用两个半自动软件Brains2在两个独立的评估者的冠状面上进行了DLPFC示踪。两个独立评估者之间的类内相关系数，左DLPFC为0.94，右DLPFC为0.93。平均值±标准偏差左半球的DLPFC体积为9.23±2.35 ml，右半球的DLPFC体积为8.20±2.08 ml。我们提出的方法具有较高的评估者间可靠性，并且易于实现，从而可以对该区域进行标准化测量以用于临床研究应用。

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