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首页> 外文期刊>Psychiatry Research. Neuroimaging >Object recognition deficit in early- and adult-onset schizophrenia regardless of age at disease onset
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Object recognition deficit in early- and adult-onset schizophrenia regardless of age at disease onset

机译：不论发病年龄如何，早发和成年精神分裂症的对象识别缺陷

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Perceptual closure is the ability of the brain to recognize a complete object based on fragmentary information and has been known to be impaired in schizophrenia. Here, the neural integrity of perceptual closure in schizophrenia with different disease onsets was evaluated by examining the generation of event-related potential (ERP) components (P100, N180, and Ncl).ERPs were recorded from 40 patients (19 early-onset schizophrenia, "EOS" and 21 adult-onset schizophrenia, "AOS") and 40 age-matched healthy volunteers. Brain electric source analysis (BESA) was applied to localize the cerebral generators underlying perceptual closure. Patients showed an impaired generation of Ncl and P100 components. P100 and Ncl amplitudes were significantly reduced in both AOS and EOS (P0.01). Moreover, N180 and Ncl amplitudes were significantly increased with age in controls and patients (P0.01). In the case of the Ncl, there was also a significant interaction (P0.001) between age and group, indicating a greater age-dependent Ncl increase in controls compared to patients. Visual information processing during perceptual closure is impaired in schizophrenia, regardless of age at disease onset. The combined influence of age and group on the amplitude of the Ncl might support the idea of neurodevelopmental deficits in schizophrenia.
机译：知觉闭合是大脑基于碎片信息识别完整物体的能力，并且已知在精神分裂症中会受损。在这里，通过检查事件相关电位（ERP）组分（P100，N180和Ncl）的生成来评估不同疾病发作的精神分裂症知觉闭合的神经完整性。记录了40例患者（19例早发精神分裂症）的ERPs。 ，“ EOS”和21位成人发作的精神分裂症，“ AOS”）和40位年龄相匹配的健康志愿者。应用脑电源分析（BESA）来定位感知闭合基础下的脑源。患者显示Ncl和P100成分的产生受损。在AOS和EOS中，P100和Ncl振幅均显着降低（P <0.01）。此外，对照组和患者中，N180和Ncl振幅随年龄显着增加（P <0.01）。在Ncl的情况下，年龄与组之间也存在显着的相互作用（P <0.001），这表明与患者相比，对照中Ncl的年龄依赖性更大。精神分裂症患者在知觉性闭合期间的视觉信息处理能力受损，无论其发病年龄如何。年龄和群体对Ncl振幅的综合影响可能支持精神分裂症的神经发育缺陷。

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