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首页> 外文期刊>Psychiatry Research. Neuroimaging >Corpus callosum morphology and relationship to orbitofrontal and lateral ventricular volume in teenagers with first-presentation borderline personality disorder
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Corpus callosum morphology and relationship to orbitofrontal and lateral ventricular volume in teenagers with first-presentation borderline personality disorder

机译：初发性交界型人格障碍青少年的体形态及其与眶额和侧脑室容积的关系

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Previous studies have demonstrated alterations to fronto-limbic circuitry and callosal structure in borderline personality disorder (BPD). We predicted that a first-presentation BPD cohort who demonstrated orbitofrontal cortex (OFC) reductions would show regional reductions in the anterior corpus callosum. Method: Twenty teenage first-presentation BPD patients and twenty matched healthy controls underwent Magnetic resonance imaging (MRI) was performed in 20 teenaged first-presentation BPD patients and 20 matched healthy controls. Corpus callosum size and shape and ventricular volume were estimated using established methods and compared between the two groups. The relationship between illness variables and callosal morphology was also examined. OFC volume was correlated with callosal and ventricular variables. Results: BPD participants and controls did not differ on measures of callosal size or shape, or ventricular size. BPD participants showed an alteration to the pattern of age-related expansions seen in the callosum. BPD participants with a history of trauma did not demonstrate significant neuroanatomical differences from those without. OFC volumes did not correlate with the thickness of the anterior corpus callosum.Condusion: Gross neuroanatomical changes are not present at the level of the callosum in teenagers with first-presentation BPD. Changes seen in other studies might reflect factors associated with the duration of BPD, such as recurrent comorbidity with axis I disorders, or treatment.
机译：先前的研究表明，在边缘性人格障碍（BPD）中，前额边缘电路和call体结构发生了改变。我们预测，首次演示BPD队列的人如果表现出眶额皮质（OFC）减少，则会显示前体的区域减少。方法：对20名青少年首次表现BPD患者和20名匹配的健康对照者进行了磁共振成像（MRI），对20名青少年首次表现BPD患者和20名匹配的健康对照者进行了磁共振成像。使用既定方法估算estimated体大小，形状和心室容积，并在两组之间进行比较。还检查了疾病变量和call形态之间的关系。 OFC体积与call和心室变量相关。结果：BPD参与者和对照组在call体大小或形状或心室大小的测量上没有差异。 BPD参与者显示出在the中见到的与年龄有关的扩张模式的改变。具有创伤史的BPD参与者与没有创伤史的BPD参与者没有显示出明显的神经解剖学差异。结论：对于初次表现为BPD的青少年，the的水平没有明显的神经解剖学改变。在其他研究中观察到的变化可能反映了与BPD持续时间相关的因素，例如复发性合并I轴疾病或治疗。

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