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首页> 外文期刊>Psychiatry Research. Neuroimaging >Reduction of dorsolateral prefrontal cortex gray matter in late-life depression.
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Reduction of dorsolateral prefrontal cortex gray matter in late-life depression.

机译：在晚期抑郁症中减少背外侧前额叶皮层灰质。

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Postmortem studies have documented abnormalities in the dorsolateral prefrontal cortex (dlPFC) in depressed subjects. In this study we used magnetic resonance imaging to test for dlPFC volume differences between older depressed and non-depressed individuals. Eighty-eight subjects meeting DSM IV criteria for major depressive disorder and thirty-five control subjects completed clinical evaluations and cranial 3T magnetic resonance imaging. After tissue types were identified using an automated segmentation process, the dlPFC was measured in both hemispheres using manual delineation based on anatomical landmarks. Depressed subjects had significantly lower gray matter in the left and right dorsolateral prefrontal cortex (standardized to cerebral parenchyma) after controlling for age and sex. Our study confirmed the reduction of dorsolateral prefrontal cortex in elderly depressed subjects, especially in the gray matter. These regional abnormalities may be associated with psychopathological changes in late-life depression.
机译：事后研究已证明抑郁症患者的背外侧前额叶皮层（dlPFC）异常。在这项研究中，我们使用磁共振成像测试了老年抑郁症患者和非抑郁症患者之间dlPFC的体积差异。符合DSM IV标准的重度抑郁症的88位受试者和35位对照受试者完成了临床评估和颅骨3T磁共振成像。在使用自动分割过程识别出组织类型之后，使用两个基于解剖标志的手动划定法在两个半球中测量了dlPFC。在控制了年龄和性别之后，抑郁的受试者的左右背外侧前额叶皮层（标准化为脑实质）的灰质明显降低。我们的研究证实了老年抑郁症患者的背外侧前额叶皮层减少，尤其是在灰质中。这些区域异常可能与晚期抑郁症的心理病理变化有关。

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