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Structural evidence for involvement of a left amygdala-orbitofrontal network in subclinical anxiety

机译：左杏仁核-眶额网络参与亚临床焦虑的结构性证据

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Functional neuroimaging implicates hyperactivity of amygdala-orbitofrontal circuitry as a common neurobiological mechanism underlying the development of anxiety. Less is known about anxiety-related structural differences in this network. In this study, a sample of healthy adults with no history of anxiety disorders completed a 3T MRI scan and self-report mood inventories. Post-processing quantitative MRI image analysis included segmentation and volume estimation of subcortical structures, which were regressed on anxiety inventory scores, with depression scores used to establish discriminant validity. We then used a quantitative vertex-based post-processing method to correlate (1) anxiety scores and (2) left amygdala volumes with cortical thickness across the whole cortical mantle. Left amygdala volumes predicted anxiety, with decreased amygdala volume associated with higher anxiety on both state and trait anxiety measures. A negative correlation between left amygdala volume and cortical thickness overlapped with a positive correlation between anxiety and cortical thickness in left lateral orbitofrontal cortex. These results suggest a structural anxiety network that corresponds with a large body of evidence from functional neuroimaging. Such findings raise the possibility that structural abnormalities may result in a greater vulnerability to anxiety or conversely that elevated anxiety symptoms may result in focal structural changes.
机译：功能性神经影像学暗示杏仁核-眶额叶回路的过度活跃，是焦虑症发展的常见神经生物学机制。人们对该网络中与焦虑相关的结构差异知之甚少。在这项研究中，没有焦虑症史的健康成年人样本完成了3T MRI扫描和自我报告情绪清单。处理后的定量MRI图像分析包括皮质下结构的分割和体积估计，这些结构根据焦虑量表评分进行回归，而抑郁评分可用于判别有效性。然后，我们使用基于顶点的定量后处理方法，将（1）焦虑评分和（2）左杏仁核体积与整个皮层中的皮层厚度相关联。左杏仁核体积预测焦虑，状态和性状焦虑量度指标均显示杏仁核体积减少与较高焦虑相关。左杏仁核体积和皮质厚度之间的负相关与焦虑和左侧眶额叶皮质的皮质厚度之间的正相关重叠。这些结果表明结构性焦虑网络与来自功能性神经影像学的大量证据相对应。这些发现增加了结构异常可能导致更大的焦虑脆弱性的可能性，或者相反，焦虑症状升高可能导致局灶性结构改变。

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