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首页> 外文期刊>Psychiatry Research. Neuroimaging >Preliminary evidence for white matter metabolite differences in marijuana-dependent young men using 2D J-resolved magnetic resonance spectroscopic imaging at 4 Tesla
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Preliminary evidence for white matter metabolite differences in marijuana-dependent young men using 2D J-resolved magnetic resonance spectroscopic imaging at 4 Tesla

机译：在4特斯拉使用2D J分辨磁共振波谱成像在依赖大麻的年轻男子中白质代谢物差异的初步证据

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摘要

Chronic marijuana (MRJ) use is associated with altered cognition and mood state, altered brain metabolites, and functional and structural brain changes. The objective of this study was to apply proton magnetic resonance spectroscopic imaging (MRSI) to compare proton metabolite levels in 15 young men with MRJ dependence and 11 healthy non-using (NU) young men. Spectra were acquired at 4.0 Tesla using 2D J-resolved MRSI to resolve coupled resonances in .J-space and to quantify the entire J-coupled spectral surface of metabolites from voxels containing basal ganglia and thalamus, temporal and parietal lobes, and occipital white and gray matter. This method permitted investigation of high-quality spectra for regression analyses to examine metabolites relative to tissue type. Distribution of myo-inositol (mI)/creatine (Cr) was altered in the MRJ group whereas the NU group exhibited higher mI/Cr in WM than GM, this pattern was not observed in MRJ subjects. Significant relationships observed between global mI/Cr and distribution in WM, and self-reported impulsivity and mood symptoms were also unique between MRJ and NU groups. These preliminary findings suggest that ml, and distribution of this glial metabolite in WM, is altered by MRJ use and is associated with behavioral and affective features reported by young MRJ-dependent men.
机译：慢性大麻（MRJ）的使用与认知和情绪状态改变，脑代谢物改变以及脑功能和结构改变有关。这项研究的目的是应用质子磁共振波谱成像（MRSI）来比较15名患有MRJ依赖的年轻男性和11名健康不使用（NU）的年轻男性的质子代谢产物水平。使用2D J分辨MRSI在4.0 Tesla上获得光谱，以解析.J空间中的耦合共振，并量化包含基础神经节和丘脑，颞叶和顶叶以及枕叶白色和白色的体素的代谢物的整个J耦合光谱表面。灰质。这种方法可以研究高质量的光谱，进行回归分析，以检查相对于组织类型的代谢物。在MRJ组中，肌醇（mI）/肌酸（Cr）的分布发生了变化，而NU组在WM中的mI / Cr高于GM，在MRJ组中未观察到这种模式。在MRJ和NU组之间，观察到的总体mI / Cr与WM中的分布之间的重要关系以及自我报告的冲动性和情绪症状也很独特。这些初步发现表明，MRJ的使用会改变WM中神经胶质代谢产物的ml和分布，并与依赖MRJ的年轻男性报告其行为和情感特征有关。

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