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首页> 外文期刊>Psychiatry Research. Neuroimaging >Fronto-striatal underactivation during interference inhibition and attention allocation in grown up children with attention deficit/hyperactivity disorder and persistent symptoms.
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Fronto-striatal underactivation during interference inhibition and attention allocation in grown up children with attention deficit/hyperactivity disorder and persistent symptoms.

机译：在患有注意缺陷/多动障碍和持续性症状的成年儿童中，干扰抑制和注意力分配期间的额叶纹状体激活不足。

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Attention deficit hyperactivity disorder (ADHD) in medication-naive children has been associated with reduced activation in inferior/medial prefrontal, striatal and parieto-temporal cortices during inhibitory control and attention allocation. Functional magnetic resonance imaging (fMRI) studies in adult ADHD, however, have been inconsistent and confounded by medication-history and the need for a retrospective diagnosis of childhood ADHD. We used fMRI combined with a Simon task that measured interference inhibition and controlled for and co-measured attention allocation to compare brain function in 11 medication-naive adults with persistent inattentive/hyperactive behaviours, followed up from childhood ADHD, and 15 age-matched controls. Despite comparable task performance, patients showed reduced activation compared to controls in left orbital/medial frontal cortex and striatum during interference inhibition and in left lateral inferior/dorsolateral prefrontal cortex during attention allocation. Whole-brain regression analyses within patients showed a negative correlation between symptom severity and fronto-striatal, temporo-parietal and cerebellar brain activation. The findings demonstrate that the typical fronto-striatal dysfunction observed in children with ADHD during interference inhibition and attention allocation is also observed in adults grown up from childhood ADHD with persistent symptoms. Furthermore, they show that functional deficits in adult ADHD are not related to chronic stimulant medication given that this sample was medication-naive.
机译：初次使用药物的儿童中的注意力缺陷多动障碍（ADHD）与抑制控制和注意力分配过程中下/中前额叶，纹状体和顶颞皮层的激活减少有关。然而，成人用药多动症的功能磁共振成像（fMRI）研究一直不一致，并因药物治疗史和对儿童多动症的回顾性诊断而感到困惑。我们将fMRI与Simon任务结合使用，该任务测量干扰抑制并控制和共同测量注意力分配，以比较11名未接受药物治疗且持续性的注意力不集中/过度活跃的成年人，儿童ADHD和15位年龄相匹配的对照者的脑功能。尽管具有可比的任务表现，但在干扰抑制期间，患者的左眼眶/内侧额叶皮层和纹状体以及在注意分配过程中，左外侧下/背外侧前额叶皮层的激活均低于对照组。患者的全脑回归分析显示症状严重程度与额纹状体，颞顶叶和小脑大脑激活之间呈负相关。这些发现表明，在多动症儿童中，在干扰抑制和注意力分配过程中观察到的典型的额叶纹状体功能障碍也出现在自患有持续性症状的儿童多动症儿童的成年人中。此外，他们表明，鉴于该样本是未经药物治疗的，成人多动症患者的功能缺陷与慢性刺激药物无关。

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