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首页> 外文期刊>Psychiatry Research. Neuroimaging >Neural correlates of sleepiness induced by catecholamine depletion
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Neural correlates of sleepiness induced by catecholamine depletion

机译：儿茶酚胺耗竭引起的嗜睡的神经相关性

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Although extensive indirect evidence exists to suggest that the central dopaminergic system plays a significant role in the modulation of arousal, the functional effect of the dopaminergic influence on the regulation of the sleep-wake cycle remains unclear. Thirteen healthy volunteers and 15 unmedicated subjects with a history of major depressive disorder underwent catecholamine depletion (CD) using oral alpha-methyl-para-tyrosine in a randomized, placebo-controlled, double-blind, crossover study. The main outcome measures in both sessions were sleepiness (Stanford-Sleepiness-Scale), cerebral glucose metabolism (positron emission tomography), and serum prolactin concentration. CD consistently induced clinically relevant sleepiness in both groups. The CD-induced prolactin increase significantly correlated with CD-induced sleepiness but not with CD-induced mood and anxiety symptoms. CD-induced sleepiness correlated with CD-induced increases in metabolism in the medial and orbital frontal cortex, bilateral superior temporal cortex, left insula, cingulate motor area and in the vicinity of the periaqueductal gray. This study suggests that the association between dopamine depletion and sleepiness is independent of the brain reward system and the risk for depression. The visceromotor system, the cingulate motor area, the periaqueductal gray and the caudal hypothalamus may mediate the impact of the dopaminergic system on regulation of wakefulness and sleep.
机译：尽管存在大量间接证据表明中枢多巴胺能系统在唤醒的调节中起着重要作用，但是多巴胺能对睡眠-唤醒周期调节的功能作用尚不清楚。在一项随机，安慰剂对照，双盲，交叉研究中，使用口服α-甲基-对-酪氨酸对13名健康志愿者和15名有重大抑郁症史的非药物受试者进行儿茶酚胺耗竭（CD）。两次会议的主要结局指标是嗜睡（Stanford-Sleepiness量表），脑葡萄糖代谢（正电子发射断层扫描）和血清催乳素浓度。 CD持续在两组中诱发临床相关的嗜睡。 CD引起的催乳素增加与CD引起的嗜睡显着相关，但与CD引起的情绪和焦虑症状无关。 CD引起的嗜睡与CD引起的内侧和眶额叶皮层，双侧颞叶上皮层，左岛岛，扣带回运动区以及导水管周围灰质的代谢增加有关。这项研究表明，多巴胺消耗与嗜睡之间的关联与大脑奖励系统和抑郁风险无关。内脏运动系统，扣带运动区，导水管周围灰色和尾下丘脑可能介导多巴胺能系统对清醒和睡眠调节的影响。

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