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首页> 外文期刊>Psychiatry Research. Neuroimaging >Altered transfer of visual motion information to parietal association cortex in untreated first-episode psychosis: Implications for pursuit eye tracking
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Altered transfer of visual motion information to parietal association cortex in untreated first-episode psychosis: Implications for pursuit eye tracking

机译:视觉运动信息向未经治疗的首发性精神病的顶叶缔合皮层的转移转移:对追踪眼动的暗示

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摘要

Visual motion processing and its use for pursuit eye movement control represent a valuable model for studying the use of sensory input for action planning. In psychotic disorders, alterations of visual motion perception have been suggested to cause pursuit eye tracking deficits. We evaluated this system in functional neuroimaging studies of untreated first-episode schizophrenia (N= 24), psychotic bipolar disorder patients (N= 13) and healthy controls (N= 20). During a passive visual motion processing task, both patient groups showed reduced activation in the posterior parietal projection fields of motion-sensitive extrastriate area V5, but not in V5 itself. This suggests reduced bottom-up transfer of visual motion information from extrastriate cortex to perceptual systems in parietal association cortex. During active pursuit, activation was enhanced in anterior intraparietal sulcus and insula in both patient groups, and in dorsolateral prefrontal cortex and dorsomedial thalamus in schizophrenia patients. This may result from increased demands on sensorimotor systems for pursuit control due to the limited availability of perceptual motion information about target speed and tracking error. Visual motion information transfer deficits to higher-level association cortex may contribute to well-established pursuit tracking abnormalities, and perhaps to a wider array of alterations in perception and action planning in psychotic disorders.
机译:视觉运动处理及其在追求眼球运动控制中的应用代表了一种有价值的模型,可用于研究将感官输入用于行动计划。在精神病性疾病中,已经提出视觉运动感知的改变会引起追赶眼跟踪缺陷。我们在未经治疗的首发精神分裂症(N = 24),精神病性双相情感障碍患者(N = 13)和健康对照(N = 20)的功能性神经影像研究中评估了该系统。在进行被动视觉运动处理任务期间,两个患者组在运动敏感的条纹状区域V5的顶壁后投射区域均显示出减少的激活,但在V5本身中却没有。这表明减少了视觉运动信息从顶皮层皮层到顶叶缔合皮层的知觉系统的自下而上的传递。在积极追求中,精神分裂症患者的两组患者前顶壁内沟和岛沟以及背外侧前额叶皮层和背部丘脑的激活均得到增强。由于与目标速度和跟踪误差有关的感知运动信息的可用性有限,这可能是由于对传感器电机系统进行跟踪控制的需求增加所致。视觉运动信息传递缺陷到更高级别的联想皮层可能会导致建立良好的追踪跟踪异常,并可能导致精神病患者的感知和行动计划发生更大范围的变化。

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