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首页> 外文期刊>Psychiatry Research. Neuroimaging >The 5-HT 2A receptor and serotonin transporter in Asperger's Disorder: A PET study with [ 11C]MDL 100907 and [ 11C]DASB
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The 5-HT 2A receptor and serotonin transporter in Asperger's Disorder: A PET study with [ 11C]MDL 100907 and [ 11C]DASB

机译：5-HT 2A受体和5-羟色胺转运蛋白在阿斯伯格症中的应用：[11C] MDL 100907和[11C] DASB的PET研究

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Evidence from biochemical, imaging, and treatment studies suggest abnormalities of the serotonin system in autism spectrum disorders, in particular in frontolimbic areas of the brain. We used the radiotracers [ 11C]MDL 100907 and [ 11C]DASB to characterize the 5-HT 2A receptor and serotonin transporter in Asperger's Disorder. Seventeen individuals with Asperger's Disorder (age=34.3±11.1years) and 17 healthy controls (age=33.0±9.6years) were scanned with [ 11C]MDL 100907. Of the 17 patients, eight (age=29.7±7.0years) were also scanned with [ 11C]DASB, as were eight healthy controls (age=28.7±7.0years). Patients with Asperger's Disorder and healthy control subjects were matched for age, gender, and ethnicity, and all had normal intelligence. Metabolite-corrected arterial plasma inputs were collected and data analyzed by two-tissue compartment modeling. The primary outcome measure was regional binding potential BP ND. Neither regional [ 11C]MDL 100907 BP ND nor [ 11C]DASB BP ND was statistically different between the Asperger's and healthy subjects. This study failed to find significant alterations in binding parameters of 5-HT 2A receptors and serotonin transporters in adult subjects with Asperger's Disorder.
机译：生化，影像学和治疗研究的证据表明，自闭症谱系障碍，尤其是大脑前肢区域的血清素系统异常。我们使用了放射性示踪剂[11C] MDL 100907和[11C] DASB来表征阿斯伯格氏病中的5-HT 2A受体和血清素转运蛋白。用[11C] MDL 100907扫描了17例阿斯伯格疾病（年龄= 34.3±11.1岁）和17例健康对照（年龄= 33.0±9.6岁）。在17例患者中，还对8例（年龄= 29.7±7.0岁）进行了扫描。用[11 C] DASB进行扫描，八个健康对照（年龄= 28.7±7.0岁）也是如此。阿斯伯格氏病患者和健康对照者的年龄，性别和种族均相匹配，并且智力均正常。收集代谢物校正的动脉血浆输入，并通过两组织腔室模型分析数据。主要结局指标是区域结合潜力BP ND。 Asperger和健康受试者之间，区域性[11C] MDL 100907 BP ND和[11C] DASB BP ND均无统计学差异。这项研究未能发现在患有阿斯伯格症的成年受试者中5-HT 2A受体和5-羟色胺转运蛋白的结合参数有显着改变。

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