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首页> 外文期刊>Psychiatry Research. Neuroimaging >Semantic fluency deficits and reduced grey matter before transition to psychosis: A voxelwise correlational analysis
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Semantic fluency deficits and reduced grey matter before transition to psychosis: A voxelwise correlational analysis

机译：过渡到精神病之前的语义流畅性缺陷和减少的灰质：体素相关分析

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Early identification of subjects with an increased risk of psychosis is necessary to develop interventions to delay or prevent disease onset. We recently reported that decreased semantic verbal fluency performance in ultra high risk (UHR) subjects predicts the development of psychosis (Becker et al., 2010). The present study investigated whether semantic and verbal fluency scores correlate with grey matter density in UHR subjects. Thirty-seven UHR subjects underwent structural MRI scanning and verbal fluency assessment after which they were followed up for 2 years. Using voxel-based morphometry, we investigated whether grey matter density correlated with verbal fluency scores in 10 UHR subjects who developed psychosis during follow-up and 27 UHR subjects who did not develop psychosis. In UHR subjects developing psychosis, lower semantic fluency scores correlated significantly with reduced grey matter density in the right superior and middle temporal gyrus, the right insula, and the left anterior cingulate cortex. This study shows that a correlation between semantic fluency performance and grey matter density in task-related areas can differentiate between UHR subjects who subsequently will develop psychosis and those who will not. Combining these two measures could improve psychosis prediction in UHR subjects.
机译：尽早发现患有精神病的风险较高的受试者是开发干预措施以延迟或预防疾病发作所必需的。我们最近报道说，超高风险（UHR）受试者语义言语流利性的下降预示了精神病的发展（Becker等，2010）。本研究调查了UHR受试者的语义和言语流畅性分数是否与灰质密度相关。 37名UHR受试者接受了结构MRI扫描和言语流畅性评估，之后进行了2年的随访。使用基于体素的形态计量学，我们调查了在随访期间发生精神病的10名UHR受试者和未发生精神病的27名UHR受试者中灰质密度是否与口语流利度得分相关。在发展为精神病的UHR受试者中，较低的语义流利度得分与右上颞中回，右岛和左前扣带回皮层的灰质密度降低显着相关。这项研究表明，在与任务相关的区域中，语义流畅性表现与灰质密度之间的相关性可以区分随后会发展为精神病的UHR受试者和不会患精神病的UHR受试者。结合这两种措施可以改善UHR受试者的精神病预测。

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