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首页> 外文期刊>Psychiatry Research. Neuroimaging >Default mode network dysfunction in adults with prenatal alcohol exposure
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Default mode network dysfunction in adults with prenatal alcohol exposure

机译：成人产前酒精暴露的默认模式网络功能障碍

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摘要

Prenatal alcohol exposure (PAE) is known to cause significant cognitive and attentional dysfunction. Given the relationship between default mode network (DMN) activity and task-related attentional modulation, it is possible that PAE affects activity of this network. In the present study, task-related deactivation as well as structural and resting state functional connectivity of the DMN were examined using diffusional tensor imaging and functional magnetic resonance imaging in non-dysmorphic and dysmorphic PAE populations and compared to healthy controls. The dysmorphic PAE group was found to have reduced DMN deactivation as compared to controls, indicating poorer attentional modulation during the cognitive task. Additionally, structural connectivity and baseline functional connectivity were lower in both PAE groups as compared to controls. Primarily the findings suggest that learning problems seen with PAE may be a combination of general attentional and specific cognitive deficits. A secondary implication is that DMN activity is affected to varying extents depending on the degree of PAE.
机译：众所周知，产前酒精暴露（PAE）会引起严重的认知和注意力障碍。给定默认模式网络（DMN）活动和与任务相关的注意力调制之间的关系，PAE可能会影响此网络的活动。在本研究中，使用扩散张量成像和功能磁共振成像在非畸形和畸形PAE人群中检查了与任务相关的失活以及DMN的结构和静止状态功能连接，并与健康对照进行了比较。发现与对照相比，畸形的PAE组的DMN失活减少，表明在认知任务期间注意力调节较差。此外，与对照组相比，两个PAE组的结构连接性和基线功能连接性均较低。最初的发现表明，PAE出现的学习问题可能是一般注意力和特定认知缺陷的组合。第二个含义是，DMN的活性受PAE程度的影响程度不同。

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