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首页> 外文期刊>Psychiatry Research. Neuroimaging >Altered fimbria-fornix white matter integrity in anorexia nervosa predicts harm avoidance.
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Altered fimbria-fornix white matter integrity in anorexia nervosa predicts harm avoidance.

机译：神经性厌食症中纤维-穹ni白质完整性的改变预示着可以避免伤害。

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摘要

The eating disorder anorexia nervosa (AN) is associated with high anxiety. The brain mechanisms that drive those behaviors are unknown. In this study we wanted to test whether brain white matter (WM) integrity is altered in AN, and related to heightened anxiety. Sixteen adult women with AN (mean age 24 +/- 7 years) and 17 healthy control women (CW, mean age 25 +/- 4 years) underwent diffusion tensor imaging (DTI) of the brain. The DTI brain images were used to calculate the fractional anisotropy (FA) of WM tracts, which is a measure for WM integrity. AN individuals compared to CW showed clusters of significantly reduced FA (p<0.05, corrected) in the bilateral fimbria-fornix and the fronto-occipital fasciculus, as well as the posterior cingulum WM. In the AN group, Harm Avoidance was predicted by FA in the left and right fimbria-fornix. Those findings were not due to WM volume deficits in AN. This study indicates that WM integrity is abnormal in AN in limbic and association pathways, which could contribute to disturbed feeding, emotion processing and body perception in AN. The prediction of Harm Avoidance in AN by fimbria-fornix WM integrity suggests that this pathway may be mechanistically involved in high anxiety in AN.
机译：进食障碍神经性厌食症（AN）与高度焦虑相关。驱动这些行为的大脑机制尚不清楚。在这项研究中，我们想测试是否在AN中改变了脑白质（WM）的完整性，并与焦虑加剧有关。 16名成年女性AN（平均年龄24 +/- 7岁）和17名健康对照女性（CW，平均年龄25 +/- 4岁）接受了脑弥散张量成像（DTI）。 DTI脑图像用于计算WM道的分数各向异性（FA），这是WM完整性的度量。与CW相比，AN个体在双侧胫骨前额肌和额枕筋膜以及后扣带WM中显示出明显减少的FA簇（p <0.05，已校正）。在AN组中，FA预测左，右纤维膜-穹ni处会避免伤害。这些发现不是由于AN中WM体积不足。这项研究表明，在边缘和缔合途径的AN中，WM完整性异常，这可能导致AN中的进食，情感加工和身体知觉受阻。纤维膜-穹niWM完整性对AN避免伤害的预测表明，该途径可能与AN的高度焦虑有关。

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