• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Psychiatry Research. Neuroimaging >Functional connectivity in major depression: Increased phase synchronization between frontal cortical EEG-source estimates
【24h】

Functional connectivity in major depression: Increased phase synchronization between frontal cortical EEG-source estimates

机译：严重抑郁症的功能连通性：额叶皮层脑电图来源估计之间的相位同步增加

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Structural and metabolic alterations in prefrontal brain areas, including the subgenual (SGPFC), medial (MPFC) and dorsolateral prefrontal cortex (DLPFC), have been shown in major depressive disorder (MDD). Still it remains largely unknown how brain connectivity within these regions is altered at the level of neuronal oscillations. Therefore, the goal was to analyze prefrontal electroencephalographic phase synchronization in MDD and its changes after antidepressant treatment. In 60 unmedicated patients and 60 healthy controls (HC), a 15-min resting electroencephalogram (EEG) was recorded in subjects at baseline and in a subgroup of patients after 2 weeks of antidepressant medication. EEG functional connectivity between the SGPFC and the MPFC/DLPFC was assessed with eLORETA (low resolution brain electromagnetic tomography) by means of lagged phase synchronization. At baseline, patients revealed increased prefrontal connectivity at the alpha frequency between the SGPFC and the left DLPFC/MPFC. After treatment, an increased connectivity between the SGPFC and the right DLPFC/MPFC at the beta frequency was found for MDD. A positive correlation was found for baseline beta connectivity and reduction in scores on the Hamilton depression rating scale. MDD is characterized by increased EEG functional connectivity within frontal brain areas. These EEG markers of disturbed neuronal communication might have potential value as biomarkers.
机译：在重度抑郁症（MDD）中已显示出额前脑区域的结构和代谢变化，包括亚属（SGPFC），内侧（MPFC）和背外侧前额皮质（DLPFC）。在这些区域内的大脑连通性如何在神经元振荡的水平上改变，仍然很大程度上还是未知的。因此，目的是分析抗抑郁药治疗后MDD的前额叶脑电图相位同步及其变化。在60名未接受药物治疗的患者和60名健康对照（HC）中，抗抑郁药物治疗2周后，基线时受试者和亚组患者中记录了15分钟的静息脑电图（EEG）。通过滞后相位同步，通过eLORETA（低分辨率脑电磁层析成像）评估了SGPFC和MPFC / DLPFC之间的EEG功能连通性。基线时，患者显示SGPFC和左DLPFC / MPFC之间的α频率前额叶连接性增加。治疗后，发现MDD在SGPFC和正确的DLPFC / MPFC之间以beta频率增强了连接。发现基线β连通性和汉密尔顿抑郁量表评分的降低呈正相关。 MDD的特征是额叶脑区域内的EEG功能连接性增强。这些EEG标记的神经元沟通障碍可能具有作为生物标记物的潜在价值。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号