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首页> 外文期刊>Psychiatry Research. Neuroimaging >Brain white matter microstructure in deficit and non-deficit subtypes of schizophrenia
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Brain white matter microstructure in deficit and non-deficit subtypes of schizophrenia

机译：精神分裂症的缺陷和非缺陷亚型的脑白质微观结构

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Dividing schizophrenia into its deficit (SZD) and nondeficit (SZND) subtypes may help to identify specific and more homogeneous pathophysiological characteristics. Our aim was to define a whole brain voxelwise map specifically characterizing white matter tracts of schizophrenia patients with and without the deficit syndrome. We compared microstructural diffusion-related parameters as measured by diffusion tensor imaging in 21 SZD patients, 21 SZND patients, and 21 healthy controls, age- and gender-matched. Results showed that fractional anisotropy was reduced in the right precentral area in SZND patients, and in the left corona radiata of the schizophrenia group as a whole. Axial diffusivity was reduced in the left postcentral area of SZD patients and in the left cerebellum of the whole schizophrenia group. Radial diffusivity was increased in the left forceps minor of SZD patients, in the left internal capsule of SZND patients, and in the right inferior fronto-occipital fasciculus in the whole schizophrenia group. Mean diffusivity was increased from healthy controls to SZD patients to SZND patients in the right occipital lobe. In conclusion, SZD patients are not simply at the extreme end of a severity continuum of white matter disruption. Rather, the SZD and SZND subtypes are associated with distinct and specific brain microstructural anomalies that are consistent with their peculiar psychopathological dimensions. (C) 2014 Elsevier Ireland Ltd. All rights reserved,
机译：将精神分裂症分为其缺陷型（SZD）和非缺陷型（SZND）亚型可能有助于确定特定且更为均一的病理生理特征。我们的目的是定义一个全脑三维图，专门描述患有和不患有缺乏症的精神分裂症患者的白质束。我们比较了通过扩散张量成像测量的21位SZD患者，21位SZND患者和21位年龄和性别匹配的健康对照者的微结构扩散相关参数。结果显示，精神分裂症组的整体中，SZND患者的右前中央区域和左冠状放射线的分数各向异性减小。 SZD患者的左中后区域和整个精神分裂症组的左小脑的轴向扩散性均降低。在整个精神分裂症组中，SZD患者的左小镊子，SZND患者的左内囊和右下额枕筋膜的径向扩散性增加。从正常对照组到SZD患者到右枕叶的SZND患者的平均扩散率增加。总之，SZD患者不仅处于白质破坏严重程度连续性的极端。相反，SZD和SZND亚型与独特而特殊的脑微结构异常有关，这与它们独特的心理病理学维度一致。 （C）2014 Elsevier Ireland Ltd.保留所有权利，

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