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首页> 外文期刊>Psychiatry Research. Neuroimaging >Corpus callosum abnormalities in medication-naive adult patients with obsessive compulsive disorder
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Corpus callosum abnormalities in medication-naive adult patients with obsessive compulsive disorder

机译：未经药物治疗的成年强迫症成年患者的体异常

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摘要

Emerging evidence demonstrates widespread abnormalities involving white matter (WM) tracts connecting different cortical regions in obsessive-compulsive disorder (OCD). The corpus callosum (CC), the largest interhemispheric tract connecting the association cortices, has been shown to be affected in OCR This study examines CC abnormalities in a large sample of medication-naive OCD patients in comparison to matched healthy controls (HCs). We examined the mid-sagittal area of the CC in medication-naive OCD patients (n=49) in comparison with age-, sex-, and handedness-matched HCs (n=38). Witelson's method was used to measure the sub-regions of the CC - namely, the genu, body, isthmus and splenium - with good interrater reliability. The area of the body of the CC and total CC area were significantly larger in OCD patients than in HCs after controlling for age, sex and intracranial area. The Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) compulsion score had a significant negative correlation with the areas of the isthmus and splenium of the CC in addition to the total CC area. The region-specific differences in the body of the CC and the region-specific association of severity score with posterior regions of the CC might be indicative of the involvement of additional areas like the dorsolateral prefrontal cortex, posterior parietal areas, occipital and association cortices in OCD that extend beyond the conventional orbito-fronto-striatal circuitry that is often posited to be involved in OCD. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
机译：新兴证据表明，强迫症（OCD）中涉及连接不同皮质区域的白质（WM）道的广泛异常。 call体（CC）是连接联想皮层的最大半球间束，已显示在OCR中受到影响。这项研究检查了与未经治疗的正常OCD患者相比，与相匹配的健康对照（HCs）相比，CC异常的情况。我们检查了未接受药物治疗的强迫症患者（n = 49）与年龄，性别和手性匹配的HCs（n = 38）相比，CC的矢状面中部面积。维特森（Witelson）的方法用于测量CC的子区域，即膝部，身体，峡部和脾脏-具有良好的内在可靠性。在控制了年龄，性别和颅内面积之后，强迫症患者的CC面积和CC总面积明显大于HC。耶鲁-布朗强迫症量表（Y-BOCS）强迫评分与总CC面积及CC的峡部和脾脏面积呈显着负相关。 CC主体的区域特定差异以及严重程度评分与CC后部区域的特定区域关联可能表明其他区域的参与，例如背外侧前额叶皮层，后顶叶区域，枕叶和相关皮质OCD超出了通常被认为与OCD有关的常规眶额纹状体电路。 （C）2015 Elsevier Ireland Ltd.保留所有权利。

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