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首页> 外文期刊>Psychiatry Research. Neuroimaging >Individual differences in subcortical microstructure organization reflect reaction time performances during a flanker task: a diffusion tensor imaging study in children with and without ADHD
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Individual differences in subcortical microstructure organization reflect reaction time performances during a flanker task: a diffusion tensor imaging study in children with and without ADHD

机译：皮层下微结构组织的个体差异反映了侧翼任务期间的反应时间表现：有或没有多动症的儿童的扩散张量成像研究

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摘要

The results of several previous magnetic resonance imaging studies suggest that the fronto-striatothalamic circuitry is involved in the pathophysiology of attention-deficit/hyperactivity disorder (ADHD). However, few studies have investigated the putative association between quantitative diffusion tensor imaging measurements of subcortical gray matter and subject task performances in children with ADHD. Here, we examined whether reaction time (RT) parameters during a flanker task were correlated with mean diffusivity (MD) measurements in the basal ganglia and thalamus in children with ADHD and in controls. For the study group as a whole, both the mean RT and the intra-individual variability in RTs were found to be significantly correlated with MD measurements in the right and left caudate, putamen and thalamus. In contrast, the correlation between the interference effect and MD failed to reach statistical significance. The present results may advance our understanding of the anatomical substrates of ADHD. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
机译：先前几项磁共振成像研究的结果表明额叶-纹状丘脑回路与注意力缺乏/多动障碍（ADHD）的病理生理有关。然而，很少有研究调查皮层下灰质的定量扩散张量成像测量与多动症儿童的主题任务表现之间的假定联系。在这里，我们检查了侧翼任务期间的反应时间（RT）参数是否与多动症儿童和对照组的基底神经节和丘脑的平均弥散性（MD）测量相关。对于整个研究组，均发现RT的平均RT和个体内变异均与左右尾状，壳壳和丘脑的MD测量值显着相关。相反，干扰效应和MD之间的相关性未能达到统计意义。目前的结果可能会促进我们对多动症的解剖基质的了解。 （C）2015 Elsevier Ireland Ltd.保留所有权利。

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